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GAHT has been associated with increasing ocular manifestations, but cataracts have not been previously reported. A literature review was conducted to assess for any associations between sex hormone administration and cataracts. Sparse data exist regarding the relationship between androgens and cataract. We also reviewed current knowledge derived from animal studies about oestrogen's effects on the lens, possible biomechanisms and correlations with observational data on cataract incidence with varying estrogen levels. Data surrounding parity, menarche, menopause and hormone replacement therapy in women generally supports a protective role of endogenous and exogenous estrogen on the crystalline lens. Such protection could be suppressed due to long\u2010term GAHT in susceptible individuals, but no relevant studies exist regarding cataract risk in this scenario. 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