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The follow\u2010up rate was 92%. QUARTZ, a deep learning algorithm, was used to extract data from retinal images including arteriolar and venular diameter, tortuosity and vertical CDR. Glaucoma and AMD were self\u2010reported. IOP was measured. Multiple linear and logistic regression were used to adjust for demographic, lifestyle and clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Having wider arterioles was associated with a lower odds of glaucoma (OR\u2009=\u20090.36, 95% CI: 0.20, 0.65) at baseline but there was no association using longitudinal data. Instead, glaucoma at baseline was strongly associated with 3\u2010year change in arteriolar diameter (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.21, 95% CI: \u22120.37, \u22120.05) indicating that the cross\u2010sectional association may have been due to reverse causality. Using longitudinal data, greater venular tortuosity was associated with a reduced 3\u2010year development of glaucoma (OR\u2009=\u20090.52, 95% CI: 0.31, 0.87) and a 3\u2010year reduction in the CDR (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.006, 95% CI: \u22120.010, \u22120.002). Wider venular diameter was associated with a higher odds of AMD at baseline (OR\u2009=\u20092.77, 95% CI: 1.50, 5.15) and a higher odds of the 3\u2010year development of AMD (OR\u2009=\u20094.15, 95% CI: 1.95, 8.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Understanding the temporal relationship of changes in the retinal microvasculature and the development of eye disease may lead to better treatment and prevention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14566","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T07:58:36Z","timestamp":1749887916000},"page":"764-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retinal Vessel Traits and Age\u2010Related Eye Disease in the Canadian Longitudinal Study on Aging"],"prefix":"10.1111","volume":"53","author":[{"given":"Alexis","family":"O'Neil","sequence":"first","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan A.","family":"Welikala","sequence":"additional","affiliation":[{"name":"School of Computer Science and Mathematics Kingston University London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Barman","sequence":"additional","affiliation":[{"name":"School of Computer Science and Mathematics Kingston University London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Owen","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George's School of Health and Medical Sciences, City St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja R.","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George's School of Health and Medical Sciences, City St George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Rakesh","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010H\u00e9l\u00e8ne","family":"Roy\u2010Gagnon","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Maberley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-8427","authenticated-orcid":false,"given":"Ellen E.","family":"Freeman","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Canada"},{"name":"Department of Ophthalmology University of Ottawa  Ottawa Canada"},{"name":"Ottawa Hospital Research Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30393-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26074"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2016-000032"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02721-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.21.2388"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000888"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.041"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1459"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.10.020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.88.1.104"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.051"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.038"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.06.043"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz173"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","unstructured":"R. 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