{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T04:31:47Z","timestamp":1762662707132,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The updated simplified AREDS risk model predicts progression to late age\u2010related macular degeneration (AMD) by person, describing up to nine observations across both eyes and 10 annual risk scores (0\u20134, with\/without reticular pseudodrusen [RPD]). This study proposes an abridged model to enable inter\u2010eye comparisons and potentially enhance clinical efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 269 participants with early\/intermediate AMD over 7\u2009years. The full, person\u2010level updated simplified AREDS risk model was compared to eye\u2010level candidate risk models, derived by removing the least predictive biomarkers. The main outcomes were prognostic performance (AUC) and risk score separability (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1\u20133\u2009years, the full model showed prognostic performance (AUC\u2009\u00b1\u2009SE) up to 84.52%\u2009\u00b1\u20095.93%, with overlap between most risk scores (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\u2264\u20092.08). Removing large drusen and pigmentary abnormalities in the fellow eye, intermediate drusen in both eyes, and redefining RPD presence as eye\u2010specific maintained prognostic performance (up to 84.71%\u2009\u00b1\u20094.72%). Assigning one point per retained biomarker, based on similar adjusted risks, improved risk score separability (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\u2265\u20093.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) while reducing the number of annual scores from 10 to five.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The updated simplified AREDS risk model can be essentially halved without compromising prognostic performance by deriving eye\u2010specific biomarkers and assigning one point per biomarker (large drusen, pigmentary abnormalities, and RPD in the primary eye, and late AMD in the fellow eye). This eye\u2010level risk stratification may improve clinical efficiency and inter\u2010eye study designs when one eye is of particular interest. An example of 3\u2010year risks (scores 0\u20134) was \u22484%, 8%, 16%, 32%, and 64%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14576","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T20:38:30Z","timestamp":1751575110000},"page":"936-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proposal of a Simpler Eye\u2010Level Risk Model Incorporating Reticular Pseudodrusen for the Clinical Prediction of Late\n                    <scp>Age\u2010Related Macular Degeneration<\/scp>"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6184-0666","authenticated-orcid":false,"given":"Matt","family":"Trinh","sequence":"first","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annita","family":"Duong","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Cheung","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"},{"name":"Vision Eye Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ng","sequence":"additional","affiliation":[{"name":"Vision Eye Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Vision Eye Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Hodge","sequence":"additional","affiliation":[{"name":"Vision Eye Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Nivison\u2010Smith","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Ly","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-97"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.035279"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.233"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12964"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2102061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1570"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.04.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.03.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1017-7"},{"key":"e_1_2_8_12_1","unstructured":"RANZCO \u201cRANZCO: Referral Pathway for AMD Management \u201d2024."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.036"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.85"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238072"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002886"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.11.013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.035"},{"key":"e_1_2_8_19_1","unstructured":"RANZCO \u201cRANZCO: Fluorescein and Indocyanine Green Angiography Guidelines \u201d2023."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.03.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa302"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01218-1"},{"key":"e_1_2_8_23_1","unstructured":"J. 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