{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:43Z","timestamp":1787014003840,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100024713","name":"Australian and New Zealand Eye Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to characterise visual acuity (VA) changes in eyes without baseline macular atrophy (MA) that subsequently developed MA during treatment for neovascular age\u2010related macular degeneration (nAMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control analysis was performed using data from a multicentre real\u2010world AMD registry. We compared VA outcomes in 1998 treatment\u2010na\u00efve eyes without MA at baseline and \u2265\u20095\u2009years of follow\u2010up. Two matched groups (999 eyes each) were analysed: eyes that developed incident MA and those that never did.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Comparisons were made between two matched groups of 999 eyes each with incident MA and those that never developed it with at least 5\u2009years of follow\u2010up. Final VA was best in eyes that never developed MA, followed by eyes that developed extrafoveal and sub\u2010foveal MA (68.9\u2009\u00b1\u200916.7, 67.0\u2009\u00b1\u200916.9 and 52.1\u2009\u00b1\u200923.6 letters,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Eyes with incident MA had more inactive disease visits compared to those that never developed MA. Features associated with poor final VA included the presence of sub\u2010foveal MA (odds ratio [OR] [95% confidence interval (CI)] \u221216.63 [\u221218.7 to 14.56],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and a higher proportion of active visits (per 10%) (OR [95% CI] \u22120.73 [\u22121.12 to 0.34],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The mean time to lose five letters of vision from first grading of sub\u2010foveal MA was 17.3\u2009\u00b1\u20094.6\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is important to achieve disease inactivity in nAMD despite its association with incident MA, as neovascular complications play a significant role in VA loss. The long duration between the incidence of MA and clinically significant loss of vision offers an opportunity for potential interventions against atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14587","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:50:00Z","timestamp":1754286600000},"page":"925-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progression of Loss of Vision From Centre\u2010Involving Macular Atrophy in Eyes Treated for nAMD"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7458-7081","authenticated-orcid":false,"given":"Kelvin Y. C.","family":"Teo","sequence":"first","affiliation":[{"name":"Singapore Eye Research Institute  Singapore Singapore"},{"name":"Advanced Eye Clinic and Surgery  Singapore Singapore"},{"name":"Save Sight Institute, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodorus Leonardus","family":"Ponsioen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Isala Clinic  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sioe","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Gelre Hospital  Apeldoorn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"OToole","sequence":"additional","affiliation":[{"name":"Mater Private Network Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Arruabarrena Sanchez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Principe de Asturias  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Barry","sequence":"additional","affiliation":[{"name":"Blink Eye Clinic  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Brosa","family":"Morros","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology Vall Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine","family":"Chung","sequence":"additional","affiliation":[{"name":"Strathfield Retina  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-1987","authenticated-orcid":false,"given":"Alessandro","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of 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