{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:04:25Z","timestamp":1788372265465,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the 10\u2010year cumulative incidence, progression rates, and risk factors for macular atrophy (MA) in neovascular age\u2010related macular degeneration (nAMD) patients receiving long\u2010term anti\u2010vascular endothelial growth factor (VEGF) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, multicenter, cohort study including 148 eyes from 140 nAMD patients treated with a pro\u2010re\u2010nata (PRN) anti\u2010VEGF regimen and followed for \u2265\u200910\u2009years. Annual multimodal imaging\u2014including blue autofluorescence [BAF], spectral\u2010domain optical coherence tomography [SD\u2010OCT] and near\u2010infrared reflectance\u2014was reviewed to detect and quantify MA using RegionFinder. Kaplan\u2013Meier analysis estimated cumulative MA incidence, while mixed\u2010effects Cox and linear regressions identified risk factors and progression rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline MA prevalence was 23.0%, increasing to 64.9% at 5\u2009years and 79.8% at 10\u2009years. Foveal involvement occurred in 47.4% of cases. Significant predictors for MA included baseline BCVA &lt;\u200920\/40 (HR\u2009=\u20091.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), greater central subfield thickness (CST) fluctuations (HR\u2009=\u20091.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and more frequent submacular haemorrhages (HR\u2009=\u20091.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Type 3 macular neovascularization was associated with fovea\u2010involving MA (HR\u2009=\u20092.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Mean MA size increased from 0.34 to 2.27\u2009mm at 10\u2009years, progressing at 0.20\u2009mm\/year (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Eyes with incident MA exhibited faster progression (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and worse BCVA decline compared to those with baseline MA (\u22121.96 vs. \u22121.42 letters\/year,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>nAMD patients treated with PRN anti\u2010VEGF therapy demonstrated a high 10\u2010year cumulative incidence of MA (79.8%), with poor baseline BCVA and CST fluctuations as key risk factors. Eyes with incident MA progressed faster and were associated with greater visual decline, suggesting a more visually impactful atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14608","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T14:24:09Z","timestamp":1758291849000},"page":"55-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ten\u2010Year Incidence, Risk Factors and Progression Rate of Macular Atrophy in Neovascular Age\u2010Related Macular Degeneration"],"prefix":"10.1111","volume":"54","author":[{"given":"Francesco","family":"Romano","sequence":"first","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Casaluci","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department 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