{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:48:40Z","timestamp":1773265720586,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We analysed 12\u2010month real\u2010world outcomes of treatment of eyes with neovascular age\u2010related macular degeneration switched to brolucizumab from a first\u2010generation VEGF inhibitor to determine whether switching chronically active eyes that required frequent treatment improved control of the disease safely with fewer injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of Australian and Italian data from the prospectively designed observational Fight Retinal Blindness! registry. We studied eyes that switched to brolucizumab and received at least two injections with 12\u2009months of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 81 eligible eyes, the proportion of inactive lesions increased from 5% at baseline to 37% 12\u2009months after switching to brolucizumab (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Mean (95% CI) visual acuity (VA) was stable (0.6 [\u22121.5, 2.8] letters,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55), while median treatment intervals increased from 44 to 63\u2009days (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Nearly a third (30%) of eyes switched back to another VEGF inhibitor within 12\u2009months. Eyes that stayed on brolucizumab had a significantly longer mean treatment interval at 12\u2009months than eyes that switched off it (66.1 [Q1, Q3: 56, 91] vs. 49 [28, 63.2] days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001) while VA change and inactivation rates were similar. Intraocular inflammation (IOI) was recorded in 7 (9%) eyes receiving at least one injection of brolucizumab.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eyes that switched from a first generation VEGF inhibitor to brolucizumab in routine clinical practice achieved a clinically significant extension of their treatment interval, with more than a third becoming inactive but with a relatively high rate of IOI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70033","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T11:07:26Z","timestamp":1763636846000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twelve\u2010Month Outcomes of Brolucizumab in Routine Clinical Practice: Fight Retinal Blindness! Registry"],"prefix":"10.1111","volume":"54","author":[{"given":"Trung M.","family":"Dang","sequence":"first","affiliation":[{"name":"Eye Clinic Albury Wodonga  Albury New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"},{"name":"Eye Clinic, Department of Biomedical and Clinical Science Luigi Sacco Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0458-9727","authenticated-orcid":false,"given":"Francesco","family":"Romano","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Science Luigi Sacco Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-2461","authenticated-orcid":false,"given":"Mariano","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Science Luigi Sacco Hospital, University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Arnold","sequence":"additional","affiliation":[{"name":"Eye Clinic Albury Wodonga  Albury New South Wales Australia"},{"name":"Marsden Eye Specialists  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Wong","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"},{"name":"Strathfield Retina Clinic  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemal","family":"Mehta","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"},{"name":"Strathfield Retina Clinic  Sydney New South Wales Australia"},{"name":"Department of Ophthalmology Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Fraser\u2010Bell","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"},{"name":"Sydney Eye Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Barry","sequence":"additional","affiliation":[{"name":"Blink Eye Clinic Canberra  Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Barthelmes","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"},{"name":"Department of Ophthalmology University Hospital Zurich and University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gillies","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Luckie","sequence":"additional","affiliation":[{"name":"Eye Clinic Albury Wodonga  Albury New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01554-2"},{"key":"e_1_2_8_3_1","article-title":"Affinity and Potency of RTH258 (ESBA1008), A Novel Inhibitor of Vascular Endothelial Growth Factor A for the Treatment of Retinal Disorders","volume":"56","author":"Tietz J.","year":"2015","journal-title":"Investigative Ophthalmology & Visual 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