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Multimodal imaging features can raise early clinical suspicion to support appropriate subspecialty referrals and treatment for patients affected by these conditions. This review synthesises current evidence on the diagnostic and prognostic value of characteristic imaging features of these rare malignancies. Findings are reviewed based on imaging modality, including fundus photography, optical coherence tomography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, optical coherence tomography angiography, and ultrasound. We emphasise discriminative biomarkers that heighten suspicion for either vitreoretinal or choroidal lymphoma, as well as key findings to discriminate between lymphoma and alternative diagnoses. We further describe longitudinal changes in multimodal imaging features that can facilitate tracking disease progression or treatment response. By consolidating modality\u2010specific findings, this review aims to facilitate early referral and accurate diagnosis of these rare malignancies.<\/jats:p>","DOI":"10.1111\/ceo.70064","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:36:02Z","timestamp":1768826162000},"page":"367-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ocular Imaging in Intraocular Lymphoma: A Review"],"prefix":"10.1111","volume":"54","author":[{"given":"Amin","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3165-5950","authenticated-orcid":false,"given":"Vishal B.","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Dalvin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Medical Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01843.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58508-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2016.1139733"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010004\u20100890\u20102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S159014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.4755"},{"issue":"81","key":"e_1_2_7_8_1","first-page":"93","article-title":"Current Concepts in Diagnosing and Managing Primary Vitreoretinal (Intraocular) Lymphoma","volume":"15","author":"Chan C. 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