{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:05:22Z","timestamp":1780542322848,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The dexamethasone intravitreal implant is used to treat sight\u2010threatening retinal disorders. Endophthalmitis is a serious complication of intravitreal injections and requires urgent intervention. Recent evidence demonstrates that the dexamethasone implant has higher endophthalmitis rates than some intravitreal injections. We present a large, prospective, state\u2010wide analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Victorian Endophthalmitis Registry prospectively identified all dexamethasone implant\u2010related endophthalmitis cases from January 2018 to June 2024 in Victoria, Australia, managed at the Royal Victorian Eye and Ear Hospital, a state\u2010wide service. The Pharmaceutical Benefits Schedule Item Reports available on the Medicare Australia database were used to determine the number of dexamethasone implants in Victoria, Australia, to calculate the incidence rate of dexamethasone implant\u2010related endophthalmitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen incidences from 9457 implants resulted in endophthalmitis (rate\u2009=\u20090.16%, 1 in 630 injections). All cases received inpatient care with an aqueous and vitreous tap, intravitreal vancomycin, and ceftazidime. Fourteen cases (93%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) underwent surgical intervention, including 13 cases of vitrectomy (87%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). A causative pathogen was isolated in 86.7% of vitreous samples (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913\/15), with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      <\/jats:styled-content>\n                      being the most common, found in seven eyes (46.7%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). Three eyes (20%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) underwent enucleation. The remaining 12 eyes had a mean follow\u2010up visual acuity of Snellen 6\/27 (logMAR 0.65\u2009\u00b1\u20090.43).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The rate of dexamethasone implant\u2010related endophthalmitis is 0.16% which is higher than other intravitreal injections reported in the literature, with considerably poor visual outcomes. The vitreous diagnostic samples are culture\u2010positive in 87% of cases (13\/15), with 46.7% (7\/15) isolating\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      <\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70066","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:22:49Z","timestamp":1770682969000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endophthalmitis After Dexamethasone Implant"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0321-0808","authenticated-orcid":false,"given":"Maryam","family":"Eghtedari","sequence":"first","affiliation":[{"name":"Vitreo\u2010Retinal Unit Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelia","family":"Chiu","sequence":"additional","affiliation":[{"name":"Vitreo\u2010Retinal Unit Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-8227","authenticated-orcid":false,"given":"Fatemeh","family":"Shams","sequence":"additional","affiliation":[{"name":"Vitreo\u2010Retinal Unit Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"},{"name":"Vitreo\u2010Retinal Unit St Helens Hospital  St Helens UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Vitreo\u2010Retinal Unit Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"},{"name":"Centre for Eye Research Australia  Melbourne Victoria Australia"},{"name":"The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-8851","authenticated-orcid":false,"given":"Rosie C. 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