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In Alzheimer's disease (AD), it shows changes like amyloid beta (A\u03b2) accumulation and vascular alterations. Pericytes modulate the glymphatic system, crucial for A\u03b2 clearance, but their role in the ocular glymphatic system is unclear. This study explores pericytes' impact on the glymphatic system and AD\u2010related retinal pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      APP\/PS1 mice, a model of progressive A\u03b2 deposition, were crossed with Pdgfr\u2010\u03b2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice, which exhibit pericyte dysfunction due to haploinsufficiency of platelet\u2010derived growth factor receptor \u03b2 (Pdgfr\u2010\u03b2), generating four littermate genotypes: wild type, Pdgfr\u2010\u03b2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      , APP\/PS1 and APP\/PS1:Pdgfr\u2010\u03b2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      . Retinal pericytes were assessed by PDGFR\u2010\u03b2 and NG 2 labelling, vascular complexity by OCTA and CD31 immunostaining and glymphatic\u2010related regulation by laminin\u2010211 and perivascular aquaporin\u20104 (AQP\u20104) expression. Retinal A\u03b2 and p\u2010Tau pathology was evaluated by immunofluorescence. Retinal A\u03b2 clearance was assessed in wild type and Pdgfr\u2010\u03b2\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      mice using intravitreal FAM\u2013A\u03b2 (1\u201342) injection followed by quantification of tracer efflux along the optic nerve to the deep cervical lymph nodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pdgfr\u2010\u03b2 knockdown exacerbated retinal pericyte loss, leading to reduced laminin\u2010211 expression, disrupted perivascular AQP\u20104 polarisation and impaired ocular glymphatic A\u03b2 clearance. Consequently, this disruption is associated with increased A\u03b2 and p\u2010Tau pathology, reduced vascular complexity and thinning of the retinal layers in APP\/PS1 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The loss of retinal pericytes is one of the major factors in retinal pathology associated with AD. It exacerbates A\u03b2 and p\u2010Tau pathology and causes retinal vascular and structural damage by affecting the function of the ocular glymphatic system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70103","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:14:18Z","timestamp":1773288858000},"page":"707-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Loss of Pericyte Exacerbates Alzheimer's Disease\u2010Associated Retinal Pathology"],"prefix":"10.1111","volume":"54","author":[{"given":"Chen","family":"Hai\u2010Chao","sequence":"first","affiliation":[{"name":"Institute of Anatomy and Histology &amp; Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University  Lanzhou Gansu People's Republic of 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