{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:00Z","timestamp":1783455240150,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare the 1\u2010year myopia control efficacy of two defocus soft contact lenses (SCLs) versus single\u2010vision spectacles in high myopic adolescents (spherical equivalent refraction [SER] of 6.00 diopters or more).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>237 participants were randomised into three groups: peripheral gradual defocus SCLs (Group A), multipoint defocus SCLs (Group B) and single\u2010vision spectacles (Group C), with 12\u2010month follow\u2010up. Outcomes included axial length change (\u0394AL), SER change (\u0394SER), choroidal thickness (CT) and choroidal vascular density (VDCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      217 subjects completed follow\u2010up. From Month 3, Group B had the smallest \u0394AL: 12\u2010month \u0394AL was (0.12\u2009\u00b1\u20090.08) mm, significantly lower than Groups A (0.25\u2009\u00b1\u20090.10\u2009mm) and C (0.48\u2009\u00b1\u20090.12\u2009mm), all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. Group B's \u0394SER (\u22120.13\u2009\u00b1\u20090.09 D) was also smaller than Groups A (\u22120.24\u2009\u00b1\u20090.11 D) and C (\u22120.45\u2009\u00b1\u20090.13 D) (all\n                      <jats:italic>p<\/jats:italic>\n                      value less than 0.05). Group B showed increased VDCC\/CT (notably 3\u2010mm foveal area), Group C decreased and Group A stabilised. Multiple regression indicated Group B intervention (\u03b2\u2009=\u2009\u22120.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and 3\u2010mm CT change (\u03b2\u2009=\u2009\u22120.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) independently correlated with smaller \u0394AL (model\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.35,\n                      <jats:italic>p<\/jats:italic>\n                      value less than 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multipoint defocus SCLs outperform other methods in controlling high myopia and improving choroidal parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70120","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:19:51Z","timestamp":1777097991000},"page":"617-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Efficacy of Two Defocus Soft Contact Lenses on Axial Length and Choroid in High Myopic Adolescents"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-6827","authenticated-orcid":false,"given":"Jia","family":"Yu","sequence":"first","affiliation":[{"name":"Beijing Huade Ophthalmology Hospital Co., Ltd.  Beijing China"},{"name":"Ming Vision and Ophthalmology Jianguomen Branch Clinic  Beijing China"},{"name":"Ineye\u00a0Hospital of Chengdu University of Traditional Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Yushi Eye Clinic  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.5.3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00231-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.5.6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000066"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3182990878"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2018.11.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-4534.305035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.12.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14773"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.10.011"},{"issue":"8","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2024-003187","article-title":"Comparison of the Performance of Myopia Control in European Children and Adolescents With Defocus Incorporated Multiple Segments (DIMS) and Highly Aspherical Lenslets (HAL) Spectacles","volume":"31","author":"Lembo A.","year":"2024","journal-title":"BMJ Paediatrics Open"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2025.100588"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303914"},{"issue":"8","key":"e_1_2_9_15_1","first-page":"1369","article-title":"Research Progress on Molecular Mechanism of Scleral Remodeling and Intervention in High Myopia","volume":"20","author":"Zhang Y.","year":"2020","journal-title":"Int Eye Sci"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0335526"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001410"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000036"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.035"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12332"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000894"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2020.03.018"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000867"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-321815"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.12.014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-024-01051-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161535"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000495"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)00233-C"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)E0049-Q"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.70120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:23:20Z","timestamp":1783452200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.70120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/ceo.70120"],"URL":"https:\/\/doi.org\/10.1111\/ceo.70120","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}