{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:13:08Z","timestamp":1791645188965,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ab\u2010interno canaloplasty (ABiC) may be performed as a standalone procedure or in combination with phacoemulsification (ABiC+Phaco). This study aims to examine the comparative surgical outcomes of both procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, EMBASE and CENTRAL were searched for randomised controlled trials, cohort studies and retrospective case series published from inception to 31 March 2025 that compared outcomes of standalone ABiC and ABiC+Phaco in the treatment of open\u2010angle glaucoma (OAG). Random\u2010effects meta\u2010analysis was performed to pool the mean difference in intraocular pressure (IOP) and glaucoma medications compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies with a pooled total of 663 eyes were included in final analysis. There was no significant difference in IOP\u2010lowering efficacy between ABiC+Phaco and standalone ABiC across all timepoints (6\u2009months, 1\u2009year, 2\u2009years and 3\u2009years) with a mean difference of 0.25\u2009mmHg (95% CI: \u22120.98 to 1.48) at 3\u2009years. There was also no significant difference in glaucoma medication reduction between ABiC+Phaco and standalone ABiC across all timepoints, with a mean difference of 0.03 medication reduction (95% CI: \u22120.18 to 0.23) at 3\u2009years. A small IOP\u2010lowering benefit of ABiC+Phaco versus standalone ABiC in primary OAG\u2010only studies (mean difference 0.75\u2009mmHg, 95% CI: 0.03\u20131.47) was observed at 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our meta\u2010analysis suggests that phacoemulsification may not offer significant additional IOP and glaucoma medication reduction to standalone ABiC. However, results should be interpreted with caution due to a moderate risk of bias across all included studies. Regardless, our findings are consistent with existing literature on the effect of adjunctive phacoemulsification on other ab\u2010interno MIGS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70124","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:20:08Z","timestamp":1778023208000},"page":"678-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Efficacy of Standalone Ab\u2010Interno Canaloplasty Versus Ab\u2010Interno Canaloplasty Combined With Phacoemulsification: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-0406","authenticated-orcid":false,"given":"Hon Jen","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Medicine Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankai","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Medicine Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devy","family":"Anggreni","sequence":"additional","affiliation":[{"name":"Department of Medicine Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor J.","family":"Yeong","sequence":"additional","affiliation":[{"name":"Department of Medicine Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng Yang","family":"Lim","sequence":"additional","affiliation":[{"name":"Army Medical Services, Singapore Armed Forces  Singapore Singapore"},{"name":"Department of 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