{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:26:10Z","timestamp":1787955970573,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009783","name":"S:t Eriks \u00d6gonforskningsstiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transpupillary thermotherapy (TTT) is used for selected small choroidal melanocytic tumours, either as primary treatment or as an adjunct to plaque brachytherapy. We compared long\u2010term local recurrence and mortality outcomes after primary TTT alone, plaque brachytherapy combined with TTT (brachy+TTT), and plaque brachytherapy alone (brachy alone).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 850 patients with choroidal melanocytic tumours treated with eye\u2010preserving modalities at St. Erik Eye Hospital, Stockholm, Sweden, 2008\u20132020. Primary treatment was TTT alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948), brachy+TTT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009105), or brachy alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009697). Outcomes included local recurrence, local recurrence with extraocular extension (EXE), and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 15\u2009years, Kaplan\u2013Meier local recurrence\u2010free survival was 8% after TTT alone, 34% after brachy+TTT, and 86% after brachy alone (log\u2010rank test for trend,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Disease\u2010specific survival at 15\u2009years was 46%, 85%, and 90%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). In multivariable Fine\u2013Gray regression adjusting for American Joint Committee on Cancer stage, TTT alone was associated with a higher subdistribution hazard of local recurrence (sHR, 6.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and melanoma\u2010related death (sHR, 3.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among patients treated for local recurrence, subsequent recurrences occurred more frequently after TTT than after treatments involving brachytherapy. The risk of EXE increased with the number of TTT sessions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single\u2010centre retrospective cohort, TTT was associated with higher rates of local recurrence and melanoma\u2010related mortality compared with plaque brachytherapy. Future studies should assess whether similar results are observed in external long\u2010term cohorts; such findings would inform whether the role of TTT in the management of choroidal melanocytic tumours warrants reconsideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70126","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:30:13Z","timestamp":1778297413000},"page":"832-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010Term Local Control and Mortality After Transpupillary Thermotherapy of Small Uveal Melanomas"],"prefix":"10.1111","volume":"54","author":[{"given":"Maria","family":"Fili","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience, Division of Eye and Vision Karolinska Institutet  Stockholm Sweden"},{"name":"Ocular Oncology Service, St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Ermedahl Conradi","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Klaff Dahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Division of Eye and Vision Karolinska Institutet  Stockholm Sweden"},{"name":"Ocular Oncology Service, St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Sabazade","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Casselholm De Salles","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-8911","authenticated-orcid":false,"given":"Gustav","family":"St\u00e5lhammar","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Division of Eye and Vision Karolinska Institutet  Stockholm Sweden"},{"name":"Ocular Oncology Service, St. Erik Eye Hospital  Stockholm Sweden"},{"name":"St. Erik Ophthalmic Pathology Laboratory St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14214"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00005-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100030071024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.132951"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.11.1370"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.7.933"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.09.029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01327.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.12.033"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.3.397"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700512"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02171-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00858-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.079001019.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.077"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000516536"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00445-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2022.101152"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315722"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-313419"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2023.133614"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.70404"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.70381"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1646040"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2014.05.018"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68232-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2771"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17582"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00902-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1733-6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1762925"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.133249"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2025.152469"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067211002000126"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-5520-2_2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00161146"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00063-X"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.11.1512"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2002.800106.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2024.09.004"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.11.021"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03961-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.10.026"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.70126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:55:12Z","timestamp":1786510512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.70126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ceo.70126"],"URL":"https:\/\/doi.org\/10.1111\/ceo.70126","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}