{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:29:13Z","timestamp":1786512553059,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare acute\u2010phase macular ganglion cell\u2013inner plexiform layer (GCIPL) thickness on optical coherence tomography (OCT) between Leber hereditary optic neuropathy (LHON) and optic neuritis (ON), and to evaluate the diagnostic performance of nasal GCIPL thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective single\u2010centre study, OCT (CIRRUS HD\u2010OCT; Carl Zeiss Meditec, Dublin) acquired within 45\u2009days of symptom onset was analysed. Sectoral GCIPL thickness was compared between LHON and ON\u2014including double\u2010seronegative (DN\u2010ON), aquaporin\u20104 antibody\u2013positive (AQP4\u2010ON) and myelin oligodendrocyte glycoprotein antibody\u2013positive (MOG\u2010ON) subtypes\u2014using linear mixed\u2010effects models adjusted for age, sex and onset\u2010to\u2010OCT interval. Receiver operating characteristic (ROC) analyses evaluated nasal GCIPL thickness (average of superonasal and inferonasal sectors) alone and combined with clinical covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LHON showed significantly thinner GCIPL than ON in the superonasal (adjusted mean difference \u221212.1\u2009\u03bcm) and inferonasal (\u221212.4\u2009\u03bcm) sectors in the acute phase (FDR\u2010adjusted\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u20090.02 and 0.01, respectively). The nasal GCIPL difference was evident versus DN\u2010ON and MOG\u2010ON, whereas separation from AQP4\u2010ON was less apparent. Nasal GCIPL thickness alone discriminated LHON from ON with an area under the curve (AUC) of 0.88 (Youden\u2010optimal cut\u2010off 72.5\u2009\u03bcm; sensitivity 0.93, specificity 0.82); a multivariable model including age, sex and onset\u2010to\u2010OCT category increased the AUC to 0.94.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute\u2010phase OCT reveals nasal\u2010predominant GCIPL thinning in LHON. This pattern differentiates LHON from DN\u2010ON and MOG\u2010ON but is less distinct from AQP4\u2010ON. Nasal GCIPL thickness, alone or combined with clinical covariates, may aid differential diagnosis in acute presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70130","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:50:24Z","timestamp":1778896224000},"page":"845-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nasal\u2010Predominant\n                    <scp>Ganglion Cell\u2010Inner Plexiform Layer<\/scp>\n                    Thinning Distinguishes Early\u2010Stage Leber Hereditary Optic Neuropathy From Acute Optic Neuritis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7971-8258","authenticated-orcid":false,"given":"Yasuyuki","family":"Takai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Inouye Eye Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Inouye Eye Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Inouye Eye Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Orthoptics and Visual Science, School of Allied Health Sciences Kitasato University  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"},{"name":"Department of Neurology National Hospital Organization Yonezawa National Hospital  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Animal Model Development, Brain Research Institute Niigata University  Niigata Japan"},{"name":"Department of Multiple Sclerosis Therapeutics, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.11.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000570"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.06.034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307326"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14061998"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"339","article-title":"Designation Criteria for Leber's Hereditary Optic Neuropathy","volume":"119","author":"Nakamura M.","year":"2015","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00431-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00200-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-020-00789-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10452"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000002384"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.540156"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519864928"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.03.001"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.70130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:55:11Z","timestamp":1786510511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.70130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ceo.70130"],"URL":"https:\/\/doi.org\/10.1111\/ceo.70130","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"2026-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}