{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:29:16Z","timestamp":1786512556861,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3P0191"],"award-info":[{"award-number":["CMRPG3P0191"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3P0051\u20132"],"award-info":[{"award-number":["CMRPG3P0051\u20132"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010182A\u2010040"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010182A\u2010040"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate ocular blood flow in school\u2010aged children born prematurely, with or without retinopathy of prematurity (ROP), using laser speckle flowgraphy (LSFG), and to determine factors associated with LSFG\u2010derived parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional observational study included 123 school\u2010aged preterm children: 54 without ROP, 20 with untreated type 2\/mild ROP, and 49 with treated type 1 ROP. All participants underwent ophthalmic examinations and optic nerve head (ONH) perfusion assessments using LSFG. Mean blur rate indices of the entire ONH (MA), vessel area (MV), and tissue area (MT) of the right eye were analysed. Multivariable generalised linear models were used to identify variables associated with LSFG parameters, and Pearson's correlation was used to examine the association between axial length and MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children with type 1 ROP had lower MA, MV, and MT than those with type 2\/mild ROP, whereas MV was the highest in the type 2\/mild ROP group. Type 1 ROP was independently associated with reduced MA and MV in the full cohort. Among children with ROP, anti\u2010vascular endothelial growth factor (VEGF) treatment was associated with lower MA, MV, and MT. Longer axial length correlated with reduced MT in both the full cohort (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and the ROP subgroup (r\u2009=\u2009\u22120.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Type 1 ROP was associated with reduced ocular blood flow in school\u2010aged children born preterm. Among eyes with ROP, a history of anti\u2010VEGF treatment was associated with lower MA, MV, and MT, although this may reflect disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70134","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:19:26Z","timestamp":1780579166000},"page":"823-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laser Speckle Flowgraphy Assessment of Ocular Blood Flow in School\u2010Aged Children With or Without a History of Retinopathy of Prematurity"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4314-2440","authenticated-orcid":false,"given":"Chin","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Education Chang Gung Memorial Hospital, Linkou Medical Center  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6814-6530","authenticated-orcid":false,"given":"Eugene Yu\u2010Chuan","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Ophthalmology Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-3059","authenticated-orcid":false,"given":"Hung\u2010Da","family":"Chou","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Ophthalmology Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan\u2010Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Ophthalmology Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Ophthalmology Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Ophthalmology Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Shiou","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Ophthalmology Chang Gung Memorial Hospital  Linkou 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