{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:50:12Z","timestamp":1791366612203,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00207"],"award-info":[{"award-number":["PI23\/00207"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To report the 1\u2010year clinical outcomes of decellularised human corneal stromal lamina implantation, with or without autologous adipose\u2010derived adult stem cells (ADASCs), for advanced keratoconus in a European cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, randomised Phase I\/IIa trial, 10 eyes of 10 patients were allocated to decellularised stromal lamina implantation alone (G\u20101;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) or lamina recellularised with 1.0\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      autologous ADASCs plus 2.0\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      additional ADASCs injected into the stromal pocket (G\u20102;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). All procedures used femtosecond laser\u2010assisted 9.5\u2010mm intrastromal dissection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No major intraoperative complications occurred except one G\u20102 micro\u2010tear that resolved. No clinically relevant inflammation, rejection, or graft failure was observed; transparency was restored in all eyes by 3\u20136\u2009months. At 12\u2009months, central corneal thickness increased by 118.4\u2009\u03bcm in G\u20101 and 121.2\u2009\u03bcm in G\u20102. Decimal UDVA improved by 2.14\u2009\u00b1\u20090.71 lines in G\u20101 and 1.30\u2009\u00b1\u20090.84 lines in G\u20102; decimal CDVA improved by 2.48\u2009\u00b1\u20090.66 and 1.43\u2009\u00b1\u20090.53 lines, respectively. Manifest sphere improved to \u22121.10 D in G\u20101 and \u22120.58 D in G\u20102, whereas manifest cylinder changed minimally in both groups. Keratometric indices remained largely unchanged. In\u00a0vivo confocal microscopy demonstrated progressive cellular repopulation of the implanted lamina during follow\u2010up in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decellularised stromal lamina implantation, with or without autologous ADASCs, was safe and feasible, maintaining corneal transparency and producing sustained stromal thickening with clinically meaningful visual and refractive improvement at 12\u2009months. Larger adequately powered studies with longer follow\u2010up are required to assess clinical efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70141","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:26:44Z","timestamp":1783481204000},"page":"883-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decellularised Corneal Stromal Lamina With or Without Autologous Adipose\u2010Derived Adult Stem Cells for Advanced Keratoconus: 1\u2010Year Results of a Phase I\/\n                    <scp>IIa<\/scp>\n                    Clinical Trial"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2585-1659","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"Cornea, Cataract and Refractive Surgery Unit, Vissum (Miranza Group)  Alicante Spain"},{"name":"Division of Ophthalmology School 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