{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:49:07Z","timestamp":1791402547206,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This trial aimed to evaluate the efficacy of oral acetazolamide in reducing cystoid fluid collections (CFC) and improving visual function in patients with X\u2010linked retinoschisis (XLRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this investigator\u2010initiated, single centre, open\u2010label, randomised controlled trial, XLRS patients aged \u2265\u200912\u2009years with fovea\u2010involving CFC at baseline were eligible. Participants were randomised 1:1 to receive either oral acetazolamide (500\u2009mg\/day for 16\u2009weeks, followed by tapering or discontinuation based on response) or no treatment (control) for 32\u2009weeks. Seven study visits were completed over 32\u2009weeks. The primary outcome was central subfield thickness (CST). Secondary outcomes included functional and structural measures, as well as patient\u2010reported visual disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 19 patients were enrolled: 10 received acetazolamide (17 eyes), and nine were monitored without treatment (16 eyes). The difference in CST from baseline up to week 32 between the treatment and control groups was on average +2.7\u2009\u03bcm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9; 95% CI, \u221268.1 to 73.5\u2009\u03bcm). Retinal sensitivity on microperimetry showed a modest statistically significant improvement favouring acetazolamide. However, no significant improvements were observed for best\u2010corrected visual acuity, low\u2010luminance visual acuity, cystoid fluid collection volume or patient\u2010reported visual disability in the treatment group compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found no clinically meaningful benefit of oral acetazolamide for reducing CFC or improving visual function in the overall XLRS population. Although structural and functional outcomes were comparable between groups overall, a small subset of patients may experience benefit, suggesting a personalised treatment approach may be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70146","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T13:58:01Z","timestamp":1786456681000},"page":"932-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomised Clinical Trial to Evaluate the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in X\u2010Linked Retinoschisis: The\n                    <scp>AXIS<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-8940","authenticated-orcid":false,"given":"Jonathan","family":"Hensman","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9654-0986","authenticated-orcid":false,"given":"Hind","family":"Almushattat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselie M. H.","family":"Diederen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien\u2010En","family":"Tan","sequence":"additional","affiliation":[{"name":"Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Oxford Eye Hospital Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilun","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute of High Performance Computing Agency for Science, Technology and Research (A*STAR)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen","family":"de Vente","sequence":"additional","affiliation":[{"name":"Quantitative Healthcare Analysis (qurAI) Group, Informatics Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam UMC Location University of Amsterdam Biomedical Engineering and Physics  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S. W.","family":"Ting","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"van Genderen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Centre Utrecht  Utrecht the Netherlands"},{"name":"Bartim\u00e9us Diagnostic Centre for Complex Visual Disorders  Zeist the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette Ossewaarde\u2010van","family":"Norel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redmer","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Centre Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha J. H.","family":"Tjon\u2010Fo\u2010Sang","sequence":"additional","affiliation":[{"name":"The Rotterdam Eye Hospital and the Rotterdam Ophthalmic Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara I.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Quantitative Healthcare Analysis (qurAI) Group, Informatics Institute University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam UMC Location University of Amsterdam Biomedical Engineering and Physics  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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