{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:50:14Z","timestamp":1791366614088,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare the safety and efficacy of trabeculectomy, PRESERFLO MicroShunt (PRESERFLO) and XEN45 Gel Stent (XEN) in patients with open\u2010angle glaucoma (OAG) during the first year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010centre retrospective case\u2013control study included 384 eyes undergoing standalone glaucoma surgery (2013\u20132020). Propensity score matching was used to balance baseline covariates. The primary outcome was surgical success at 1\u2009year. Complete success was two\u2010fold defined as an IOP of 6\u201315 or 6\u201318\u2009mmHg, without loss of light perception, additional glaucoma surgery or IOP\u2010lowering medication; qualified success allowed medication and\/or selective laser trabeculoplasty. Secondary outcomes included IOP, best\u2010corrected visual acuity, medication use and complications\/interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 117 in the trabeculectomy, 82 eyes in the PRESERFLO group and 185 in the XEN group. Complete success was lower after XEN for both IOP criteria (44.0%, IOP 6\u201318\u2009mmHg and 41.5%, IOP 6\u201315\u2009mmHg) compared to trabeculectomy (59.8% and 59.3%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and PRESERFLO (73.5% and 73.3%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). All procedures effectively and comparably reduced IOP to 12.3\u2009\u00b1\u20094.1\u2009mmHg (trabeculectomy), 12.7\u2009\u00b1\u20093.5\u2009mmHg (PRESERFLO), 13.4\u2009\u00b1\u20094.3\u2009mmHg (XEN). The proportion of drop\u2010free patients was higher after PRESERFLO (81.0% vs. 58.6% and 56.6%, after trabeculectomy and XEN, respectively). Significant hypotony was uncommon and comparably so. Minor post\u2010operative interventions were more common in trabeculectomy patients compared with PRESERFLO and XEN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests equal success rates for PRESERFLO and trabeculectomy, both outperforming XEN at 1\u2009year, with fewer post\u2010operative interventions for PRESERFLO compared to trabeculectomy. Overall complication rates were comparable across groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70147","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:25:46Z","timestamp":1785108346000},"page":"904-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of Trabeculectomy, PRESERFLO MicroShunt and XEN45 Gel Stent in Open\u2010Angle Glaucoma"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3162-7570","authenticated-orcid":false,"given":"Marie\u2010Isaline","family":"Billen Moulin\u2010Roms\u00e9e","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospitals UZ Leuven  Leuven 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