{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:04:28Z","timestamp":1789380268488,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the effect of intracameral air injection on corneal endothelial cells in patients undergoing phacoemulsification for cataracts with LOCS III nuclear grade 4 or higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective randomised clinical trial. Patients with cataracts of LOCS III nuclear grade 4 or higher were recruited from Sichuan Provincial People's Hospital between October 2024 and March 2025. Patients were randomised 1:1 to the intracameral air injection group (study group) or the conventional group (control group). Corneal endothelial parameters were assessed at 1\u2009week and 1\u2009month postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty eyes from 80 patients (mean [SD] age, 68.9 [8.4] years; 43 females [53.8%]) were randomised to the study group (40 [50.0%]) or the control group (40 [50.0%]), with 34 eyes (85.0%) and 35 eyes (87.5%) completing the 1\u2010month follow\u2010up. Postoperative endothelial cell loss (ECL) in the study group was significantly lower than in the control group at 1\u2009week (mean [SD], 6.90% [3.23%] vs. 12.81% [6.32%]; difference, \u22125.90%; 95% CI, \u22128.15% to \u22123.66%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and at 1\u2009month (mean [SD], 8.15% [3.84%] vs. 15.97% [6.11%]; difference, \u22127.82%; 95% CI, \u221210.10% to \u22125.55%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). For the secondary outcome, the study group showed a smaller increase in central corneal thickness (CCT) than the control group at 1\u2009week (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intracameral air injection was associated with lower ECL after phacoemulsification in cataracts with LOCS III nuclear grade 4 or higher. The smaller increase in CCT also suggested a potential benefit for early postoperative corneal recovery.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT06636279.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70161","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:18:48Z","timestamp":1789377528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Intracameral Air Injection on Corneal Endothelial Cell Loss After Phacoemulsification for Cataracts of\n                    <scp>LOCS III<\/scp>\n                    Nuclear Grade 4 or Higher: A Randomised Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-1066","authenticated-orcid":false,"given":"Rui","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7851-7582","authenticated-orcid":false,"given":"Ruijue","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8596-0905","authenticated-orcid":false,"given":"Shiyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8320-084X","authenticated-orcid":false,"given":"Binjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7718-3967","authenticated-orcid":false,"given":"Anqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China  Chengdu Sichuan 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