{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:14:41Z","timestamp":1788315281783,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","award":["IF2024\u201025\/5"],"award-info":[{"award-number":["IF2024\u201025\/5"]}],"id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To determine whether axial length\u2010related magnification correction in optical coherence tomography angiography (OCTA) improves machine learning classification of high myopia and resolves inconsistencies in the values and discriminatory power of OCTA microvascular metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed retinal OCTA images from a prior Hong Kong Polytechnic University study. Fourteen superficial vascular plexus metrics were extracted before and after magnification correction and used to train random forest (RF) models to classify high versus non\u2010high myopia. Outcomes included classifier performance (the area under the receiver operating characteristic curve (AUC), sensitivity, specificity and feature importance) and changes in OCTA metrics between groups before and after correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Image magnification correction significantly improved the classification of high versus non\u2010high myopia. When all 14 features were used to train the model, the AUC increased from 0.77 (fair) to 0.88 (good), and when restricted to the top five features (fractal dimension (Df), vessel length density (VLD), branchpoint density (BD), parafoveal rim VLD, and vessel area density (VAD)), similarly, from 0.79 to 0.88.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OCTA image magnification correction improves RF classification of high myopia and clarifies inconsistencies across studies. Underreported metrics, fractal dimension, parafoveal rim VLD and BD, emerged as key discriminators. Magnification correction with ML may improve characterisation of myopia\u2010related microvascular changes and enhance diagnostic precision, warranting further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70162","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:36:23Z","timestamp":1788312983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correcting Axial Length\u2010Related Magnification Errors in Optical Coherence Tomography Angiography Improves Machine Learning Classification Performance in High Myopia"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4737-6606","authenticated-orcid":false,"given":"Danuta M.","family":"Sampson","sequence":"first","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute) The University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7440-9798","authenticated-orcid":false,"given":"Mila Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute) The University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-3843","authenticated-orcid":false,"given":"Hemn","family":"Baghban Jaldian","sequence":"additional","affiliation":[{"name":"Department of Optometry, School of Rehabilitation Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-074X","authenticated-orcid":false,"given":"Madeleine S.","family":"Torcasso","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-0625","authenticated-orcid":false,"given":"Gavrielle R.","family":"Untracht","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-5469","authenticated-orcid":false,"given":"Jocelyn J.","family":"Drinkwater","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute) The University of Western Australia  Perth Australia"},{"name":"Lions Outback Vision  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-6470","authenticated-orcid":false,"given":"Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, Faculty of Health and Social Science The Hong Kong Polytechnic University  Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-3873","authenticated-orcid":false,"given":"David D.","family":"Sampson","sequence":"additional","affiliation":[{"name":"School of Computer Science and Electronic Engineering The University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-2585","authenticated-orcid":false,"given":"Andrew","family":"Lam","sequence":"additional","affiliation":[{"name":"Centre for Myopia Research, School of Optometry, Faculty of Health and Social Science The Hong Kong Polytechnic University  Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2809-9930","authenticated-orcid":false,"given":"Fred K.","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute) The University of Western Australia  Perth Australia"},{"name":"Department of Ophthalmology Royal Perth Hospital  Perth Australia"},{"name":"Ophthalmology, Department of Surgery University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird P. 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