{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:49:26Z","timestamp":1791427766304,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To report 5\u2010year outcomes in a cohort of patients who received anti\u2010VEGF therapy for macular oedema secondary to central retinal vein occlusion (CRVO) in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective observational study, 593 treatment\u2010na\u00efve eyes that commenced anti\u2010VEGF treatment between 1 January 2010, and 2019 were analysed. Outcome measures included mean changes in visual acuity (VA) and central subfield thickness (CST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the entire cohort (593), the mean VA changed by +8 letters and the mean CST by \u2212298\u2009\u03bcm. The entire cohort includes eyes with completed 5\u2010year follow\u2010up and non\u2010completers who dropped out before the end of the observation period. Eyes that completed the 5\u2010year follow\u2010up (202\/593, 34%) had a mean VA and CST change of +11 letters and \u2212320\u2009\u03bcm with a median of 25.5 injections at 39.5 visits. Non\u2010completers with a final VA of &gt;\u200970 letters (95\/593; 16%) experienced a change in mean VA of +23 letters. In non\u2010completers with a final VA between 35 and 70 letters (163\/593; 27%), the mean VA increased by 12 letters. In non\u2010completers with a final VA of &lt;\u200935 letters (133\/593; 22%), the mean VA declined by 12 letters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with macular oedema secondary to CRVO who continue treatment can achieve meaningful improvements in vision over an extended period. Patients with initially poor vision tend to have large improvements but the worst outcomes. In contrast, eyes with very good initial VA can achieve excellent functional results and may even stop treatment at some point with adequate therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.70164","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:55:30Z","timestamp":1791424530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five\u2010Year Treatment Outcomes of Macular Oedema Secondary to\n                    <scp>Central Retinal Vein Occlusion<\/scp>\n                    in Routine Clinical Practice: The Fight Retinal Blindness! Registry"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3988-4045","authenticated-orcid":false,"given":"Katrin","family":"Rudolph","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-4085","authenticated-orcid":false,"given":"Marianna","family":"Rosso","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-0274","authenticated-orcid":false,"given":"Mark","family":"Gillies","sequence":"additional","affiliation":[{"name":"Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-4679","authenticated-orcid":false,"given":"Adrian","family":"Hunt","sequence":"additional","affiliation":[{"name":"Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"},{"name":"Department of Ophthalmology Westmead Hospital  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"O'Toole","sequence":"additional","affiliation":[{"name":"Mater Private Network  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-1987","authenticated-orcid":false,"given":"Alessandro","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"},{"name":"Eye Cl\u00ednic, Department of Biomedical and Clinical Science \u201cL. Sacco\u201d Luigi Sacco Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Squirrell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Greenlane Clinical Centre and District Health Board  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9004","authenticated-orcid":false,"given":"Hemal","family":"Mehta","sequence":"additional","affiliation":[{"name":"Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"},{"name":"Department of Ophthalmology Royal Free London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-6667","authenticated-orcid":false,"given":"Richard","family":"Barry","sequence":"additional","affiliation":[{"name":"Blink Eye Clinic  Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-4845","authenticated-orcid":false,"given":"Pierre\u2010Henry","family":"Gabrielle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-4991","authenticated-orcid":false,"given":"Daniel","family":"Barthelmes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Zurich, University of Zurich  Zurich Switzerland"},{"name":"Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls [Internet]","author":"Blair K. C. C.","year":"2023"},{"key":"e_1_2_9_3_1","volume-title":"Ophthalmology","author":"Grehn F.","year":"2011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101035126"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123\u2010022\u201000534\u20107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.11.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502041"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010004\u20101087\u20104"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318296b271"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1330_22"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-021-02077-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01620-z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2020.1792937"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078538"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.3305"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102020\u2010317337"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.03.021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.012"},{"key":"e_1_2_9_20_1","first-page":"1304","article-title":"Clinical Trial Versus Real\u2010World Outcomes With Anti\u2010VEGF Therapy for Central Retinal Vein Occlusion","volume":"61","author":"Bhisitkul R. B.","year":"2020","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2023.101219"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161\u20106420(95)30849\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100964"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:55:37Z","timestamp":1791424537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":22,"alternative-id":["10.1111\/ceo.70164"],"URL":"https:\/\/doi.org\/10.1111\/ceo.70164","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2025-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ceo.70164"}}