{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:04:04Z","timestamp":1790226244689,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tattoo inflammation with uveitis (TIU) is increasingly recognised but growing case numbers have revealed substantial heterogeneity. Patients currently classified as TIU appear to include those with overt or evolving systemic sarcoidosis as well as those with isolated, pigment\u2010associated ocular inflammation. Recognition has therefore outpaced case definition. Phenotypic imprecision has clinical and scientific implications. Sarcoidosis\u2010associated TIU warrants multidisciplinary evaluation and longitudinal surveillance, whereas other presentations may reflect a localised pigment\u2010driven immune response. In rare conditions such as TIU, even modest cohort heterogeneity can obscure reproducible biological signals and impede mechanistic understanding. Recurring clinical patterns suggest distinct TIU phenotypes, with emerging translational data providing preliminary biological support for these distinctions. We therefore propose a classification framework comprising three groups: TIU\u2010R (restricted), TIU\u2010S (sarcoidosis\u2010associated), and TIU\u2010U (undifferentiated), intended to support consistent reporting, appropriate multidisciplinary referral, and coherent translational investigation. Establishing robust case definitions now will be foundational for future clinical and mechanistic research.<\/jats:p>","DOI":"10.1111\/ceo.70165","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:02:16Z","timestamp":1789426936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tattoo Inflammation With Uveitis: From Recognition to Definition"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-9218","authenticated-orcid":false,"given":"Anthea","family":"Anantharajah","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Wellington Hospital  Wellington New Zealand"},{"name":"Department of Medicine, Faculty of Medicine University of Otago  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-8316","authenticated-orcid":false,"given":"Nicolas","family":"Kluger","sequence":"additional","affiliation":[{"name":"Aava Medical Center  Kerava Finland"},{"name":"Department of Dermatology Tampere University Hospital  Tampere Finland"},{"name":"Department of Dermatology Bichat\u2010Claude Bernard Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"},{"name":"EADV Task Force on Tattoos and Body Art  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-3759","authenticated-orcid":false,"given":"Anthony J. 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