{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T03:12:58Z","timestamp":1774235578005,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Choroid plexus, a fetal organ developing approximately from the sixth week of gestation, plays a fundamental role in developing fetal brain organization. As relatively little is known about the relationship between anomalies of choroid plexuses structure and their role in brain function, we examined cases of bifid choroid plexus (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>) and discussed their potential association with lateral ventriculomegaly, other abnormal ultrasound findings, and their potential role as markers of fetal chromosomal abnormalities. In the present study, we described 23 cases of fetal<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>found in 2145 routine second trimester ultrasounds. For each patient 2<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>and 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ultrasound volumes were acquired.<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>was defined as a choroid plexus whose body was divided into two portions (arms) differently located and oriented on the three spatial axes in correspondence to the lateral ventricle, in one or both sides. The entity of the separation and reciprocal orientation of the two arms was examined. The presence of<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>in a low\u2010risk population of pregnant women undergoing routine second trimester ultrasound was showed. Lateral ventricles significantly increased in the presence of<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>. Malformations were found in four of 23 fetuses with<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>. Pregnancy outcome was favorable only in one of these four cases. We suggest that in the presence of mono or bilateral<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>without associated abnormal ultrasound findings, a closer look at fetal brain or extra\u2010cranial structures is recommended. If no related abnormalities are found, serial prenatal and postnatal sonographic follow\u2010up should be considered. In the presence of concomitant abnormal findings, genetic counseling, fetal karyotyping and magnetic resonance imaging, if possible by gestational age, are strongly advised.<\/jats:p>","DOI":"10.1111\/cga.12006","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T13:44:15Z","timestamp":1353419055000},"page":"73-77","source":"Crossref","is-referenced-by-count":2,"title":["Bifid choroid plexus: Always a normal fetal brain structure variant?"],"prefix":"10.1111","volume":"53","author":[{"given":"Giovanni","family":"Centini","sequence":"first","affiliation":[{"name":"Prenatal Diagnosis Center University of Siena Le Scotte Hospital Siena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Imperatore","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center University of Siena Le Scotte Hospital Siena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Magna Graecia Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Rosignoli","sequence":"additional","affiliation":[{"name":"P. Palagi Prenatal Diagnosis Unit Florence"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Passamonti","sequence":"additional","affiliation":[{"name":"Preconceptional and Prenatal Physiopathology Galliera Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Neonatology Unit Galliera Hospital Genova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Lituania","sequence":"additional","affiliation":[{"name":"Preconceptional and Prenatal Physiopathology Galliera Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-1456-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870190905"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.3.343"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199905)19:5<405::AID-PD552>3.0.CO;2-D"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.7.899"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1760"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010101)52:1<5::AID-JEMT3>3.0.CO;2-J"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.2.7972754"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.163.2.7518643"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199706)17:6<519::AID-PD103>3.0.CO;2-N"},{"key":"e_1_2_5_13_1","unstructured":"LeeY ChungH HwangH YoonM LeeH KimJ.Choroid plexus in normal full\u2010term neonates: sonographic classification and clinical application(1996) 3rd International Pediatric Radiology Meeting Boston."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020802"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.3.3055035"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04060448.x"},{"key":"e_1_2_5_17_1","first-page":"2823","article-title":"Rapid karyotyping in non\u2010lethal fetal malformations","volume":"1","author":"Nicolaides K","year":"1986","journal-title":"Lancet"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70363-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ar.a.20104","article-title":"Fine structural correlates of the choroid plexus of the lateral cerebral ventricle of the human fetal brain","volume":"282","author":"Scott DE","year":"2005","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.07.005"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcga.12006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T15:20:31Z","timestamp":1714576831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/cga.12006"],"URL":"https:\/\/doi.org\/10.1111\/cga.12006","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}