{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:24:39Z","timestamp":1709184279942},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alterations in histoarchitecture of the brainstem were examined immunohistochemically in 4\u2010week\u2010old rats with a single whole body <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010irradiation at a dose of 0.5, 1.0, or 1.5 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y on embryonic day (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) 15 using anti\u2010heat shock protein 25 (<jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content> immunostaining was seen in the neuronal perikarya of cranial nerve motoneurons, that is, the motor and mesencephalic nuclei of the trigeminal nerve, facial nucleus, abducens nucleus and accessory facial nucleus in the pons, and the ambiguous nucleus, dorsal nucleus of vagus nerve and hypoglossus nucleus in the medulla oblongata of intact controls. In 0.5 to 1.5 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y\u2010irradiated rats, <jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content> immunostaining in those neurons was more intense than in controls, while the most intense immunostaining was marked in 1.5 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y\u2010irradiated rats. <jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content> immunostaining was also apparent in the spinal tract of the trigeminal nerve and facial nerve tracts in 0.5 to 1.5 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y\u2010irradiated rats, but was faint in controls. Interestingly, <jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content> immunostaining was aberrantly enhanced in dendritic arbors in the magnocellular region of medial vestibular nucleus of 0.5\u20131.5 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y\u2010irradiated rats. Those arbors were identified as excitatory secondary vestibulo\u2010ocular neurons by double immunofluorescence for <jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content>\u201032. The results suggest an increase of <jats:styled-content style=\"fixed-case\">HSP25<\/jats:styled-content> expression in cranial nerve motoneurons and their related fiber tracts from prenatal exposure to ionizing irradiation. This may be an adaptive response to chronic hypoxia due to malformed brain arteries caused by prenatal ionizing irradiation.<\/jats:p>","DOI":"10.1111\/cga.12028","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T08:34:45Z","timestamp":1378370085000},"page":"87-93","source":"Crossref","is-referenced-by-count":2,"title":["Enhanced heat shock protein 25 immunoreactivity in cranial nerve motoneurons and their related fiber tracts in rats prenatally\u2010exposed to <scp>X<\/scp>\u2010irradiation"],"prefix":"10.1111","volume":"54","author":[{"given":"Kazuhiko","family":"Sawada","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Tsukuba International University  Tsuchiura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Division of Health Sciences Osaka University Graduate School of Medicine  Osaka 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