{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:45:15Z","timestamp":1770839115755,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>Cleft palate following cleft lip may include a developmental disorder during palatogenesis. CL<\/jats:styled-content>\/F<\/jats:styled-content>r mice fetuses, which develop cleft lip and palate spontaneously, have less capability for in vivo<\/jats:italic> cell proliferation in palatal mesenchyme compared with CL<\/jats:styled-content>\/F<\/jats:styled-content>r normal fetuses. In order to know the changes of signaling molecules contributing to cleft palate morphogenesis following cleft lip, the mRNA<\/jats:styled-content> expression profiles were compared in palatal shelves oriented vertically (before elevation) in CL<\/jats:styled-content>\/F<\/jats:styled-content>r fetuses with or without cleft lip. The changes in mRNA<\/jats:styled-content> profile of cleft palate morphogenesis were presented in a microarray analysis, and genes were restricted to lists contributing to cleft palate development in CL<\/jats:styled-content>\/F<\/jats:styled-content>r fetuses with cleft lip. Four candidate genes (Y<\/jats:styled-content>whab<\/jats:italic>, N<\/jats:styled-content>ek2<\/jats:italic>, T<\/jats:styled-content>acc1<\/jats:italic> and F<\/jats:styled-content>rk<\/jats:italic>) were linked in a gene network that associates with cell proliferation (cell cycle, MAPK<\/jats:styled-content>, W<\/jats:styled-content>nt and T<\/jats:styled-content>gf beta pathways). Quantitative real\u2010time RT\u2010PCR<\/jats:styled-content> highlighted the candidate genes that significantly changed in CL<\/jats:styled-content>\/F<\/jats:styled-content>r fetuses with cleft lip (Y<\/jats:styled-content>whab<\/jats:italic>, N<\/jats:styled-content>ek2<\/jats:italic> and T<\/jats:styled-content>acc1<\/jats:italic>). The results of these molecular contributions will provide useful information for a better understanding of palatogenesis in cleft palate following cleft lip. Our data indicated the genetic contribution to cleft palate morphogenesis following cleft lip.<\/jats:p>","DOI":"10.1111\/cga.12038","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T12:00:48Z","timestamp":1384171248000},"page":"94-99","source":"Crossref","is-referenced-by-count":11,"title":["Molecular contribution to cleft palate production in cleft lip mice"],"prefix":"10.1111","volume":"54","author":[{"given":"Yasunori","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Dentistry Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Taya","sequence":"additional","affiliation":[{"name":"Department of Pathology Nippon Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry Department of Oral Health and Developmental Sciences Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Pathology Nippon Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Aoba","sequence":"additional","affiliation":[{"name":"Department of Pathology Nippon Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Unit of Translational Medicine Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511401622"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2471"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi132"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth456"},{"key":"e_1_2_6_6_1","first-page":"313","article-title":"Blebs and hematomas in the lips of CL\/Fr and A\/J mice","volume":"1","author":"Brown KS","year":"1985","journal-title":"J Craniofac Genet Dev Biol Suppl"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2004.00686.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370608"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90024-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.Supplement.41"},{"key":"e_1_2_6_11_1","first-page":"336","article-title":"The genetics of cleft lip and cleft palate","volume":"22","author":"Fraser FC","year":"1970","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205711"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.2.470"},{"key":"e_1_2_6_14_1","unstructured":"GeY DudoitS SpeedTP.2003.Resampling\u2010based multiple testing for microarray data analysis Technical Report 633 Dept. of Statistics UC Berkeley. available at :http:\/\/statistics.berkeley.edu\/tech\u2010reports\/633."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.07.042"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(03)00104-3"},{"key":"e_1_2_6_17_1","first-page":"16","article-title":"Etiology of facial clefts: prospective evaluation of 428 patients","volume":"25","author":"Jones MC","year":"1988","journal-title":"Cleft Palate J"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01577.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20430"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010284"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12011"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20489"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600321"},{"key":"e_1_2_6_24_1","first-page":"117","article-title":"The effect of dam strain on the craniofacial morphogenesis of CL\/Fr mouse fetuses","volume":"15","author":"Martin DA","year":"1995","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0022"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001640104"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1997)034<0325:EOFWDS>2.3.CO;2"},{"key":"e_1_2_6_28_1","first-page":"120","article-title":"Influence of cleft lip upon palatal closure in A\/Jax mice","volume":"4","author":"Pourtois M","year":"1967","journal-title":"Cleft Palate J"},{"key":"e_1_2_6_29_1","first-page":"35","article-title":"Cleft palate\u2010 and lip\u2010related gene expression analyzed by cDNA microarray hybridization","volume":"12","author":"Saito K","year":"2002","journal-title":"Pediatr Dent J"},{"key":"e_1_2_6_30_1","first-page":"112","article-title":"Presurgical growth guidance with naso\u2010alveolar molding in infants with cleft lip and palate","volume":"43","author":"Sasaki Y","year":"2007","journal-title":"Dent Jpn (Tokyo)"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.10.1853"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.11.2073"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(63)90004-6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.01007.x"},{"key":"e_1_2_6_36_1","first-page":"99","article-title":"Deficient and delayed primary palatal fusion and mesenchymal bridge formation in cleft lip\u2010liable strains of mice","volume":"15","author":"Wang KY","year":"1995","journal-title":"J Craniofac Genet Dev Biol"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcga.12038","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cga.12038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:52:06Z","timestamp":1696294326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,21]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/cga.12038"],"URL":"https:\/\/doi.org\/10.1111\/cga.12038","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,21]]}}}