{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:57:25Z","timestamp":1791269845453,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>The birth prevalence of hypospadias increased in H<\/jats:styled-content>ungary during the last decades, thus the aim of this study was to analyze the possible role of maternal risk factors in the origin of isolated hypospadias (IHS<\/jats:styled-content>). The incidence\/prevalence of acute and chronic maternal diseases with related drug treatments were compared in the mothers of cases with IHS<\/jats:styled-content>, population controls without defect and malformed controls affected with other isolated abnormalities in the population\u2010based H<\/jats:styled-content>ungarian C<\/jats:styled-content>ase\u2010C<\/jats:styled-content>ontrol S<\/jats:styled-content>urveillance of C<\/jats:styled-content>ongenital A<\/jats:styled-content>bnormalities including 3038 cases with IHS<\/jats:styled-content>, 24\u2009814 population male controls without any defects and 11\u2009096 malformed male controls with other isolated defect. Among exposures, prospective medically recorded chronic diseases and medically recorded or retrospective maternal information regarding acute diseases and drug treatments were evaluated in the study groups. Maternal epilepsy due to the treatment of valproate (odds ratio [OR]<\/jats:styled-content> with 95% confidence interval [CI]<\/jats:styled-content>: 1.97, 1.07\u20133.61) and cervical erosion (4.09, 1.84\u20139.12) were associated with a higher risk of IHS<\/jats:styled-content>. In addition, there was an association of oral nystatin (1.94, 1.22\u20133.09), lynestrenol (26.66, 8.69\u201381.80) and ethynilestradiol (3.51, 1.61\u20137.67) treatments in the mothers of cases with a higher risk for IHS<\/jats:styled-content>. In conclusion, maternal cervical erosion, valproate, nystatin, lynestrenol and ethynilestradiol associated with a higher risk for IHS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cga.12041","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T05:04:41Z","timestamp":1385528681000},"page":"110-115","source":"Crossref","is-referenced-by-count":8,"title":["Maternal risk factors in the origin of isolated hypospadias: A population\u2010based case\u2010control study"],"prefix":"10.1111","volume":"54","author":[{"given":"Stelios","family":"Mavrogenis","sequence":"first","affiliation":[{"name":"Department of Uro\u2010oncology National Institute of Oncology Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Personality and Health Psychology E\u00f6tv\u00f6s Lor\u00e1nd University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology Semmelweis University, School of Medicine Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901113000206"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4236\/health.2010.28140"},{"key":"e_1_2_5_4_1","first-page":"1462","article-title":"Increasing trends in congenital malformations of male external organs","volume":"1","author":"Czeizel AE","year":"1985","journal-title":"Lancet"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2008.00189.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902916459"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1876818001102010009"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","unstructured":"CzeizelAE Dud\u00e1sI B\u00e1nhidyF.Interpretation of controversial teratogenic findings of drugs such as phenobarbital. ISRN Obstet Gynecol Article2011; ID 975234 8 pages.","DOI":"10.5402\/2011\/719675"},{"key":"e_1_2_5_10_1","first-page":"725","article-title":"A case\u2010control study to evaluate the risk of congenital anomalies as a resu of allylestrenol therapy during pregnancy","volume":"10","author":"Czeizel AE","year":"1988","journal-title":"Clin Ther"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540310017069"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"e_1_2_5_13_1","first-page":"329","article-title":"Increased birth prevalence of isolated hypospadias in Hungary","volume":"27","author":"Czeizel AE","year":"1986","journal-title":"Acta Paediatr Hung"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153035"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2006.00128.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66578-0"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907328"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(03)00085-9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1289\/ehp.10545","article-title":"Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta\u2010analysis","volume":"16","author":"Martin OV","year":"2008","journal-title":"Environ Health Perspect"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200107000-00017"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831060-00008"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(88)80003-0"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2605.2003.00367.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90953-E"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1785"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms002"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcga.12041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:52:14Z","timestamp":1696294334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,21]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/cga.12041"],"URL":"https:\/\/doi.org\/10.1111\/cga.12041","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,21]]}}}