{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:04:53Z","timestamp":1768442693938,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>exico is recognized as a country with a high prevalence of gastroschisis, although the cause of this remains unclear. We define the prevalence and potential risk factors for gastroschisis in a public hospital from west<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u00e9xico. A case\u2010control study was conducted among 270 newborns, including 90 patients with nonsyndromic gastroschisis (cases) and 180 infants without birth defects (controls), born all during the period 2009 to 2013 at the<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ivil de<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uadalajara \u201c<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>r.<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uan<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>enchaca\u201d (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uadalajara,<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>exico), from a total of 51\u2009145 live births. Potential maternal risk factors for gastroschisis were compared using multivariate logistic regression analysis to evaluate the deviance explained by different variables of interest. The overall prevalence of gastroschisis in live births was 17.6 per 10\u2009000 births (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 14.0\u201321.2), whereas in offspring of women \u226419 years old was 29.9 per 10\u2009000 births (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>21.9\u201338.0). Mothers \u226419 years (adjusted odds ratio [<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>] 2.8: 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.5\u20135.1), anemia during pregnancy (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>10.7; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>2.0\u201356.9), first\u2010trimester exposure to hormonal contraceptives (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>3.7; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.0\u201313.0), and first\u2010trimester alcohol consumption (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>3.4; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.6\u20137.3), were associated with gastroschisis. Contrarily, adjusted<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>for pre\u2010pregnancy body mass index \u226525\u2009kg\/m<jats:sup>2<\/jats:sup>has protective odds (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>0.2; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>0.1\u20130.5). Our results suggest an increased risk for gastroschisis among mothers under the age of 20, with anemia during pregnancy, and those who used hormonal contraceptives or consumed alcohol during early pregnancy, whereas, pre\u2010pregnancy overweight has a protective<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, and they are discussed as clues in its pathogenesis.<\/jats:p>","DOI":"10.1111\/cga.12087","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T07:45:36Z","timestamp":1411371936000},"page":"73-80","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence and risk factors for gastroschisis in a public hospital from west<scp>M<\/scp>\u00e9xico"],"prefix":"10.1111","volume":"55","author":[{"given":"Mireya","family":"Robledo\u2010Aceves","sequence":"first","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucina","family":"Bobadilla\u2010Morales","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"},{"name":"Dr. Enrique Corona Rivera Institute of Human Genetics Department of Molecular Biology and Genomics Health Sciences University Centre University of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estrella Lizbeth","family":"Mell\u00edn\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Corona\u2010Rivera","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"},{"name":"Dr. Enrique Corona Rivera Institute of Human Genetics Department of Molecular Biology and Genomics Health Sciences University Centre University of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jes\u00fas","family":"P\u00e9rez\u2010Molina","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"C\u00e1rdenas\u2010Ruiz Velasco","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Rom\u00e1n","family":"Corona\u2010Rivera","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC) Service of Genetics and Cytogenetic Unit Pediatric Division Dr. Juan I. Menchaca Civil Hospital of Guadalajara Guadalajara Mexico"},{"name":"Dr. Enrique Corona Rivera Institute of Human Genetics Department of Molecular Biology and Genomics Health Sciences University Centre University of Guadalajara Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Adolescent pregnancy. Issues in adolescent health and development. 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