{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:12:40Z","timestamp":1761718360061},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Achondroplasia and<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own syndrome are relatively common conditions individually. But co\u2010occurrence of both conditions in the same patient is rare and there have been no reports of fetal analysis of this condition by prenatal sonographic and three\u2010dimensional (3\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>) helical computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>). Prenatal sonographic findings seen in persons with<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own syndrome, such as a thickened nuchal fold, cardiac defects, and echogenic bowel were not found in the patient. A prenatal 3\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>helical<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>revealed a large head with frontal bossing, metaphyseal flaring of the long bones, and small iliac wings, which suggested achondroplasia. In a case with combination of achondroplasia and<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own syndrome, it may be difficult to diagnose the co\u2010occurrence prenatally without typical markers of<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>own syndrome.<\/jats:p>","DOI":"10.1111\/cga.12097","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T08:04:48Z","timestamp":1415693088000},"page":"116-120","source":"Crossref","is-referenced-by-count":4,"title":["Association of achondroplasia with<scp>D<\/scp>own syndrome: Difficulty in prenatal diagnosis by sonographic and 3\u2010<scp>D<\/scp>helical computed tomographic analyses"],"prefix":"10.1111","volume":"55","author":[{"given":"Akimune","family":"Kaga","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tohoku University Hospital Sendai 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