{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:57:51Z","timestamp":1789981071354,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study aimed to quantitatively characterize changes in the whole brain and arterial morphology in response to prenatal ionizing irradiation. Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and angiography (<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>) were used to evaluate brain and arterial abnormalities in 8\u2010week\u2010old male mice prenatally exposed to <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray radiation at a dose of 0.5 or 1.0 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>y on embryonic day (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>) 13. Irradiated mice demonstrated decreased brain volume, increased ventricular volume, and arterial malformation. Additionally, <jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content> signal intensity and arterial thickness in the anterior cerebral artery, middle cerebral artery, and basilar artery were lower in radiation\u2010exposed mice than in control mice. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content> are useful tools for assessing brain and arterial abnormalities after prenatal exposure to radiation.<\/jats:p>","DOI":"10.1111\/cga.12101","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T09:24:00Z","timestamp":1419326640000},"page":"103-106","source":"Crossref","is-referenced-by-count":8,"title":["Brain and arterial abnormalities following prenatal <scp>X<\/scp>\u2010ray irradiation in mice assessed by magnetic resonance imaging and angiography"],"prefix":"10.1111","volume":"55","author":[{"given":"Shigeyoshi","family":"Saito","sequence":"first","affiliation":[{"name":"Division of Health Sciences Department of Medical Engineering Osaka University Graduate School of Medicine"},{"name":"Center for Information and Neural Networks (CiNet) National Institute of Information and Communications Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Faculty of Medical and Health Sciences Tsukuba International University  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Mori","sequence":"additional","affiliation":[{"name":"Center for Information and Neural Networks (CiNet) National Institute of Information and Communications Technology"},{"name":"Biofunctional Imaging Laboratory Immunology Frontier Research Center (WPI\u2010IFReC) Osaka University  Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshichika","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Center for Information and Neural Networks (CiNet) National Institute of Information and Communications Technology"},{"name":"Biofunctional Imaging Laboratory Immunology Frontier Research Center (WPI\u2010IFReC) Osaka University  Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Murase","sequence":"additional","affiliation":[{"name":"Division of Health Sciences Department of Medical Engineering Osaka University Graduate School of Medicine"},{"name":"Center for Information and Neural Networks (CiNet) National Institute of Information and Communications Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024056"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.16.SUPPLEMENT_82"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530001453131"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860510007440"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/0955300021000038662"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370311"},{"key":"e_1_2_5_8_1","first-page":"59","article-title":"Prenatal ionizing radiation\u2010induced apoptosis of the developing murine brain with special references to the expression of some proteins","volume":"47","author":"Kitamura M","year":"2001","journal-title":"Kobe J Med 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