{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:55:49Z","timestamp":1762001749391,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"crossref","award":["OTKA 112829"],"award-info":[{"award-number":["OTKA 112829"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In most patients affected by isolated anorectal malformation (<jats:styled-content style=\"fixed-case\">IARM<\/jats:styled-content>) the etiology is largely unknown. Thus, the aim of our project was to analyze possible risk factors for<jats:styled-content style=\"fixed-case\">IARM<\/jats:styled-content>. In the first step, birth outcomes of cases with<jats:styled-content style=\"fixed-case\">IARM<\/jats:styled-content>were analyzed on the basis of maternal socio\u2010demographic variables, and these data are presented in this paper. Gestational age at delivery, birthweight, preterm birth, low birthweight and small for gestational age of cases with<jats:styled-content style=\"fixed-case\">IARM<\/jats:styled-content>were evaluated in the function of maternal age, birth\/pregnancy order, marital and employment status of mothers in the population\u2010based large dataset of the<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ungarian<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ase\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontrol<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urveillance of<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ongenital<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>bnormalities, 1980\u20131996. The study samples included 231 live\u2010born cases with<jats:styled-content style=\"fixed-case\">IARM<\/jats:styled-content>, 361 matched and 38\u2009151 population controls without any defect.<jats:styled-content style=\"fixed-case\">IARMs<\/jats:styled-content>are more frequent in males, twins and newborn infants with low birthweight and small\u2010for\u2010gestational\u2010age, the latter being the consequence of intrauterine growth restriction. In addition, mothers of cases were younger but with higher birth order, and had lower socio\u2010economic status. These maternal variables are characteristic for the gypsy population in<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ungary. The higher proportion of gypsy women among the mothers of cases with<jats:styled-content style=\"fixed-case\">IARM<\/jats:styled-content>was confirmed during the home visits of the study. Male sex and intrauterine growth restriction of cases, in addition to low socioeconomic status and gypsy origin of mothers may have a role in the risk of<jats:styled-content style=\"fixed-case\">IARMs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cga.12130","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T11:10:54Z","timestamp":1439291454000},"page":"41-45","source":"Crossref","is-referenced-by-count":2,"title":["Birth outcomes of patients with isolated anorectal malformations: A population\u2010based case\u2010control study"],"prefix":"10.1111","volume":"56","author":[{"given":"Gabor","family":"Vermes","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Military Hospital \u2013 State Health Centre Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"L\u00e1szl\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Stephen's Hospital Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Czeizel","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology Semmelweis University School of Medicine Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.21101\/cejph.a3841"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153349"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1532"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<299::AID-TERA1>3.0.CO;2-V"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07428-2_7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6876.499"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12025"},{"key":"e_1_2_7_9_1","first-page":"179","article-title":"Smoking and alcohol drinking during pregnancy. 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