{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:53:20Z","timestamp":1776462800643,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apert syndrome is a rare craniosynostosis syndrome characterized by irregular craniosynostosis, midface hypoplasia, and syndactyly of the hands and feet. Previous studies analyzed individuals with Apert syndrome and reported some facial and intraoral features caused by severe maxillary hypoplasia. However, these studies were performed by analyzing both individuals who had and those had not received a palate repair surgery, which had a high impact on the maxillary growth and occlusion. To highlight the intrinsic facial and intraoral features of Apert syndrome, five Japanese individuals with Apert syndrome from 5\u00a0years and 2\u00a0months to 9\u00a0years and 10\u00a0months without cleft palate were analyzed in this study. A concave profile and a skeletal Class III jaw\u2010base relationship caused by severe maxillary hypoplasia were seen in all patients. The patients exhibited anterior and posterior crossbites possibly due to a small dental arch of Maxilla.<\/jats:p>","DOI":"10.1111\/cga.12180","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T04:56:42Z","timestamp":1471496202000},"page":"15-23","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of the maxillofacial morphological characteristics of Apert syndrome infants"],"prefix":"10.1111","volume":"57","author":[{"given":"Hitomi","family":"Kakutani","sequence":"first","affiliation":[{"name":"Clinical Department of Orthodontics Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Division of Oral Functional Science, Graduate School of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Tsukamoto\u2010Takakusagi","sequence":"additional","affiliation":[{"name":"Clinical Department of Orthodontics Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Division of Oral Functional Science, Graduate School of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Oyama","sequence":"additional","affiliation":[{"name":"Clinical Department of Plastic Surgery Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Division of Oral Functional Science, Graduate School of Dental Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(71)90028-5"},{"key":"e_1_2_5_3_1","first-page":"5","article-title":"Genetics of craniosynostosis: review of the literature","volume":"2","author":"Ciurea AV","year":"2009","journal-title":"J Med Life"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80544-2"},{"key":"e_1_2_5_5_1","first-page":"989","article-title":"An updated pediatric perspective on the Apert syndrome","volume":"147","author":"Cohen MM","year":"1993","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470508"},{"key":"e_1_2_5_7_1","first-page":"196","article-title":"Perspectives on holoprosencephaly: Part II. 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