{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:39:36Z","timestamp":1773333576641,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We analyzed data from the Japan Environment and Children's Study (JECS), on the association between selective serotonin reuptake inhibitors (SSRI) use during pregnancy and the risk of developing of major congenital anomalies in Japan. JECS is an ongoing nationwide birth cohort study. The study includes 95\u00a0994 single pregnant women and their offspring. Among them, 172 used any SSRI up to the 12<jats:sup>th<\/jats:sup> gestational week. Crude analyses show a significantly increased incidence of upper limb, abdominal, and urogenital abnormalities. In particular, the incidence of microcephaly, hydrencephalus, esophageal atresia, small intestinal atresia, and achondroplasia was significantly higher with than without exposure to these substances. On multivariate analyses, urogenital abnormality was significant (odds ratio 3.227; 95% confidence interval: 1.460\u20137.134). This Japanese nationwide birth cohort survey clarified that the use of any SSRI until the 12<jats:sup>th<\/jats:sup> gestational week was associated with urogenital abnormality in children. The survey for association with minor classification abnormality needs further examination in Japan.<\/jats:p>","DOI":"10.1111\/cga.12202","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T05:33:13Z","timestamp":1479879193000},"page":"72-78","source":"Crossref","is-referenced-by-count":12,"title":["Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study"],"prefix":"10.1111","volume":"57","author":[{"given":"Hidekazu","family":"Nishigori","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Miyagi Japan"},{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Obara","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Tohoku University Hospital  Miyagi Japan"},{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshie","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University  Miyagi 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Center Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Ishikuro","sequence":"additional","affiliation":[{"name":"Tohoku Medical Megabank Organization Tohoku University  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Tatsuta","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiko","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuma","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University  Miyagi Japan"},{"name":"International Research Institute of Disaster Science Tohoku University  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Arima","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Nakai","sequence":"additional","affiliation":[{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Miyagi 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