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Disruption of the dynamic, sequential events of NTC can cause neural tube defects (NTD) leading to spina bifida and anencephaly in the newborn. NTC is affected by inherent factors such as genetic mutation or if the mother is exposed to certain environmental factors such as intake of harmful chemicals, maternal infection, irradiation, malnutrition, and inadequate or excessive intake of specific nutrients. Although effects of these stress factors on NTC have been intensively studied, the metabolic state of a normally developing embryo remains unclear. State\u2010of\u2010the art mass spectrometry techniques have enabled detailed study of embryonic metabolite profiles and their distribution within tissues. This approach has demonstrated that glucose metabolism is altered during NTC stages involving chorioallantoic branching. An understanding of embryonic metabolic rewiring would help reveal the etiology of NTD caused by environmental factors.<\/jats:p>","DOI":"10.1111\/cga.12219","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T18:29:04Z","timestamp":1489516144000},"page":"134-137","source":"Crossref","is-referenced-by-count":12,"title":["Neural tube closure and embryonic metabolism"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-4557","authenticated-orcid":false,"given":"Yoshifumi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Genetics, Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"},{"name":"Agency for Medical Research and Development\u2010Core Research for Evolutional Medical Science and Technology (AMED\u2010CREST) Japan Agency for Medical Research and Development  Tokyo 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