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Ingested folate becomes a functional molecule through intestinal absorption, circulation, transport to cells, and various modifications to its structure. Associations between nutritional folate status and chronic diseases such as cardiovascular disease, cancer, and cognitive dysfunction have been reported. It has also been reported that maternal folate nutritional status is related to the risk of neural tube defects (NTDs) in the offspring. It has also been recommended that folate be consumed in the diet to promote the maintenance of good health. To reduce the risk of NTDs, supplementation with folic acid (a synthetic form of folate) during the periconceptional period has also been recommended. This paper describes the basic features and nutritional role of folate.<\/jats:p>","DOI":"10.1111\/cga.12233","type":"journal-article","created":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T23:42:36Z","timestamp":1497224556000},"page":"138-141","source":"Crossref","is-referenced-by-count":151,"title":["Nutritional role of folate"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-080X","authenticated-orcid":false,"given":"Shuhei","family":"Ebara","sequence":"first","affiliation":[{"name":"School of Human Science and Environment University of Hyogo  Himeji Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119946045.ch21"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/b15413-12"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.05.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9177-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.2.353"},{"key":"e_1_2_8_7_1","first-page":"928","article-title":"Pteroylpolyglutamate hydrolase from human jejunal brush borders","volume":"261","author":"Chandler CJ","year":"1986","journal-title":"Purification and characterization The Journal of biological chemistry"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420071252-c9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420071252-c10"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70110-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665110003952"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420071252-c19"},{"key":"e_1_2_8_14_1","first-page":"219","article-title":"Chemical pathology of homocysteine. 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