{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:58:34Z","timestamp":1784818714621,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the<jats:italic>MEOX2<\/jats:italic>gene and nonsyndromic cleft palate only, this research was conducted as a case\u2013control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province, respectively. The standard procedures of genotyping the specific SNP (rs2237493) for<jats:italic>MEOX2<\/jats:italic>were performed on a StepOne Realtime PCR system with TaqMan SNP Genotyping Assays. Significant statistical differences were observed in allelic frequencies (allele T and allele G) between the non\u2010syndromic cleft palate only and control groups in female subjects, with an allelic odds ratio of 1.455 (95% confidence interval: 1.026\u20132.064) and<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05. These study findings suggest that nonsyndromic isolated cleft palate might be influenced by variation of<jats:italic>MEOX2<\/jats:italic>, especially SNP rs2237493 in Vietnamese females.<\/jats:p>","DOI":"10.1111\/cga.12259","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T10:12:38Z","timestamp":1507975958000},"page":"124-129","source":"Crossref","is-referenced-by-count":6,"title":["Association of<i>MEOX2<\/i>polymorphism with nonsyndromic cleft palate only in a Vietnamese population"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-0587","authenticated-orcid":false,"given":"Duy L.","family":"Tran","sequence":"first","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University Nagoya Japan"},{"name":"Nguyen Dinh Chieu General Hopsital Ben Tre 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