{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:35:05Z","timestamp":1788363305983,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T00:00:00Z","timestamp":1520121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We determined the overall prevalence of typical orofacial clefts and the potential risks for nonsyndromic cleft lip with or without cleft palate in a university hospital from West M\u00e9xico. For the prevalence, 227 liveborn infants with typical orofacial clefts were included from a total of 81,193 births occurred during the period 2009\u20132016 at the \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara (Guadalajara, Jalisco, Mexico). To evaluate potential risks, a case\u2010control study was conducted among 420 newborns, including only those 105 patients with nonsyndromic cleft lip with or without cleft palate (cases), and 315 infants without birth defects (controls). Data were analyzed using multivariable logistic regression analysis expressed as adjusted odds ratio with 95% confidence intervals . The overall prevalence for typical orofacial clefts was 28 per 10,000 (95% confidence interval: 24.3\u201331.6), or 1 per 358 live births. The mean values for the prepregnancy weight, antepartum weight, and pre\u2010pregnancy body mass index were statistically higher among the mothers of cases. Infants with nonsyndromic cleft lip with or without cleft palate had a significantly higher risk for previous history of any type of congenital anomaly (adjusted odds ratio: 2.7; 95% confidence interval: 1.4\u20135.1), history of a relative with cleft lip with or without cleft palate (adjusted odds ratio: 19.6; 95% confidence interval: 8.2\u201347.1), and first\u2010trimester exposures to progestogens (adjusted odds ratio: 6.8; 95% CI 1.8\u201325.3), hyperthermia (adjusted odds ratio: 3.4; 95% confidence interval: 1.1\u201310.6), and common cold (adjusted odds ratio: 3.6; 95% confidence interval: 1.1\u201311.9). These risks could have contributed to explain the high prevalence of orofacial clefts in our region of Mexico, emphasizing that except for history of relatives with cleft lip with or without cleft palate, most are susceptible of modification.<\/jats:p>","DOI":"10.1111\/cga.12276","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T16:56:01Z","timestamp":1519232161000},"page":"117-123","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence of orofacial clefts and risks for nonsyndromic cleft lip with or without cleft palate in newborns at a university hospital from West Mexico"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-2267","authenticated-orcid":false,"given":"Jorge Rom\u00e1n","family":"Corona\u2010Rivera","sequence":"first","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara Guadalajara Mexico"},{"name":"Department of Molecular Biology and Genomics, Health Sciences University Centre, \u201cDr. Enrique Corona\u2010Rivera\u201d Institute of Human Genetics University of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucina","family":"Bobadilla\u2010Morales","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara Guadalajara Mexico"},{"name":"Department of Molecular Biology and Genomics, Health Sciences University Centre, \u201cDr. Enrique Corona\u2010Rivera\u201d Institute of Human Genetics University of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Corona\u2010Rivera","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara Guadalajara Mexico"},{"name":"Department of Molecular Biology and Genomics, Health Sciences University Centre, \u201cDr. Enrique Corona\u2010Rivera\u201d Institute of Human Genetics University of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Pe\u00f1a\u2010Padilla","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Olvera\u2010Molina","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam A.","family":"Orozco\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Garc\u00eda\u2010Cruz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genomics, Health Sciences University Centre, \u201cDr. Enrique Corona\u2010Rivera\u201d Institute of Human Genetics University of Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel M.","family":"R\u00edos\u2010Flores","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetic Unit, Pediatric Division \u201cDr. Juan I. 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