{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:02:09Z","timestamp":1762999329152,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant Sprague Dawley (SD)  rats in a single dose on day 11 of pregnancy at 25 or 35\u2009mg\/kg. Fetuses on day 20 of pregnancy were externally, viscerally, and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35\u2009mg\/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs. Our findings indicated that specific types of external and skeletal anomalies were induced following flucytosine administration on day 11 of pregnancy.<\/jats:p>","DOI":"10.1111\/cga.12282","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T18:36:54Z","timestamp":1523644614000},"page":"39-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-6029","authenticated-orcid":false,"given":"Sakiko","family":"Fujii","sequence":"first","affiliation":[{"name":"Safety Research Division Safety Research Institute for Chemical Compounds Co., Ltd.  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Yabe","sequence":"additional","affiliation":[{"name":"Safety Research Division Safety Research Institute for Chemical Compounds Co., Ltd.  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kariwano\u2010Kimura","sequence":"additional","affiliation":[{"name":"Safety Research Division Safety Research Institute for Chemical Compounds Co., Ltd.  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Safety Research Division Safety Research Institute for Chemical Compounds Co., Ltd.  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouta","family":"Itoh","sequence":"additional","affiliation":[{"name":"Safety Research Division Safety Research Institute for Chemical Compounds Co., Ltd.  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Safety Research Division Safety Research Institute for Chemical Compounds Co., Ltd.  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Horimoto","sequence":"additional","affiliation":[{"name":"Faculty of Risk and Crisis Management Chiba Institute of Science  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Ancotil Package Insert.2014. Kyowa Pharmaceutical Industry Co. 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