{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:27Z","timestamp":1747183887711,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aims of this study were to test whether the Y\u2010chromosome and the autosomal <jats:italic>dominant hemimelia<\/jats:italic> (<jats:italic>Dh<\/jats:italic>) mutation can affect mandible morphology in mice. I analyzed mandible size and shape using landmark\u2010based geometric morphometrics in 16 DH\u2010Chr Y<jats:sup>@<\/jats:sup>\u2010+\/+ (@ represents one of the inbred strain names) strains and observed significant differences in mandible size. The largest mandible was identified in strain DH\u2010Chr Y<jats:sup>C3H<\/jats:sup> and the smallest in strain DH\u2010Chr Y<jats:sup>KK<\/jats:sup>. Canonical variate and discriminant function analyses suggested that the mandible shapes of strains DH\u2010Chr Y<jats:sup>C3H<\/jats:sup> and DH\u2010Chr Y<jats:sup>KK<\/jats:sup> differed from those of the other strains. Because seven of the DH\u2010Chr Y<jats:sup>@<\/jats:sup>\u2010+\/+ strains were maintained with <jats:italic>dominant hemimelia<\/jats:italic>, I also analyzed the potential influence of <jats:italic>dominant hemimelia<\/jats:italic> on mandible morphology because <jats:italic>dominant hemimelia<\/jats:italic> is known to cause various skeletal malformations. There were no significant differences in mandible size in seven sets of DH\u2010Chr Y<jats:sup>@<\/jats:sup>\u2010+\/+ and DH\u2010Chr Y<jats:sup>@<\/jats:sup>\u2010<jats:italic>Dh<\/jats:italic>\/+ strains. However, canonical variate analysis mapped strains DH\u2010Chr Y<jats:sup>CAS<\/jats:sup>\u2010<jats:italic>Dh<\/jats:italic>\/+ and DH\u2010Chr Y<jats:sup>CBA<\/jats:sup>\u2010<jats:italic>Dh<\/jats:italic>\/+ mapped distantly from the rest. Additionally, I observed similar patterns of shape change between DH\u2010Chr Y<jats:sup>CAS<\/jats:sup>\u2010+\/+ and DH\u2010Chr Y<jats:sup>CAS<\/jats:sup>\u2010<jats:italic>Dh<\/jats:italic>\/+, and between DH\u2010Chr Y<jats:sup>CBA<\/jats:sup>\u2010+\/+ and DH\u2010Chr Y<jats:sup>CBA<\/jats:sup>\u2010<jats:italic>Dh<\/jats:italic>\/+. These data indicate that the Y\u2010chromosome affects the size and shape of the mouse mandible. <jats:italic>Dominant hemimelia<\/jats:italic> affects mandible shape but not size, and its effects emerge depending on the kinds of Y\u2010chromosomes.<\/jats:p>","DOI":"10.1111\/cga.12286","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T02:00:12Z","timestamp":1525312812000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the Y\u2010chromosome and the <i>dominant hemimelia<\/i> mutation on the morphology of the mouse mandible"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-2257","authenticated-orcid":false,"given":"Jun\u2010ichi","family":"Suto","sequence":"first","affiliation":[{"name":"Institute of Agrobiological Sciences National Agriculture and Food Research Organization (NARO)  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.112.003285"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100714"},{"volume-title":"Statistical shape analysis","year":"1998","author":"Dryden IL","key":"e_1_2_7_5_1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/238351a0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300013306"},{"key":"e_1_2_7_9_1","first-page":"111","volume-title":"ICLAS manual for genetic monitoring of inbred mice","author":"Festing MFW","year":"1984"},{"key":"e_1_2_7_10_1","first-page":"231","article-title":"Inheritance and growth of mouse mutation brachypodism (brp)","volume":"26","author":"Goto M","year":"1977","journal-title":"Jikken Dobutsu"},{"key":"e_1_2_7_11_1","first-page":"121","article-title":"Mouse strain identification by means of discriminant analysis using mandible measurements","volume":"19","author":"Goto N","year":"1979","journal-title":"Natl Inst Anim Health Q"},{"key":"e_1_2_7_12_1","first-page":"70","article-title":"Genetic relationships among 5 inbred strains established from common ancestor, dd mouse, as assessed by mandible analysis","volume":"22","author":"Goto N","year":"1982","journal-title":"Natl Inst Anim Health Q"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim1978.42.1_41"},{"volume-title":"The pathology of development. 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