{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:12:06Z","timestamp":1775322726228,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Thoracolumbar supernumerary ribs (TSRs) are classified as less severe skeletal anomalies in rat developmental toxicity studies, although their incidence is relatively high in rodent studies. To investigate the characteristics of the critical window for chemically\u2010induced TSR, in this study, rats were administered 5\u2010fluorocytocine (5\u2010FC) or sodium salicylate (SAL) at one of three time periods on gestational day (GD) 9, early morning (7:00 <jats:sc>am<\/jats:sc>), midday (12:00 <jats:sc>pm<\/jats:sc> to 1:00 <jats:sc>pm<\/jats:sc>), or late afternoon (4:00 <jats:sc>pm<\/jats:sc> or 7:00 <jats:sc>pm<\/jats:sc>). The incidence of TSR and other anomalies were assessed in GD20 fetuses. A single treatment with both chemicals on GD9\u2010induced TSR, with the incidence highest when administered at 7:00 <jats:sc>Am<\/jats:sc>, decreasing gradually when administered later. This trajectory was clearer in rats treated with 5\u2010FC than with SAL. The critical period of TSR induction is shorter in rats administered 5\u2010FC than SAL. The characteristics of the critical window may cause variability in the incidence of TSR observed in developmental toxicity studies.<\/jats:p>","DOI":"10.1111\/cga.12320","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T07:00:40Z","timestamp":1543561240000},"page":"190-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Induction of a thoracolumbar supernumerary rib in rat developmental toxicity studies: A short discussion on the critical window"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2801-444X","authenticated-orcid":false,"given":"Makiko","family":"Kuwagata","sequence":"first","affiliation":[{"name":"Laboratory of Safety Evaluation, Division of Safety Hatano Research Institute, Food and Drug Safety Center  Hadano 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