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Because spontaneous abortion may result from anomalies in embryo, we questioned if an increased frequency of congenital malformation could be evidenced among cancer\u2010prone families. Oncogenetics database (\u2248193\u2009000 members) of the comprehensive cancer center Jean Perrin was crossed with regional registry of congenital malformations (\u224810 000). Among children born between 1986 and 2011, 176 children with malformation matched in both databases. In breast\/ovaries cancer\u2010prone families, the risk for malformations was multiplied by 2.4 [1.2\u20104.5] in case of a BRCA1 mutation. Frequencies of malformation in BRCA2 and MMR mutated families were similar to families without a cancer syndrome. In comparison to malformations concerning a unique anatomical system, multimalformations were significantly more frequent in case of BRCA or MMR mutations: compared to families without cancer syndrome, the risk of multimalformations was multiplied by 4.1 [0.8\u201021.7] for cancer\u2010prone families but with no known deleterious mutation, by 6.9 [1.2\u201038.6] in families with a known mutation but an unknown parental mutational status and by 10.4 [2.3\u201046.0] when one parent carried the familial mutation. No association with the type of anatomical system was found, nor with multiple births. These results suggest that BRCA and MMR genes play an important role in human embryogenesis and that if their function is lowered because of heterozygote mutations, congenital malformations are either more likely (BRCA1 mutations) and\/or more susceptible to concern several anatomical systems.<\/jats:p>","DOI":"10.1111\/cga.12329","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T14:36:42Z","timestamp":1550673402000},"page":"22-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between hereditary predisposition to common cancers and congenital multimalformations"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-3999","authenticated-orcid":false,"given":"Fabrice","family":"Kwiatkowski","sequence":"first","affiliation":[{"name":"Oncogenetics Department Centre Jean Perri (Comprehensive Cancer Center)  Clermont\u2010Ferrand France"},{"name":"Laboratory of Mathematics: Probabilities and Applied Statistics Clermont\u2010Auvergne University  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Perthus","sequence":"additional","affiliation":[{"name":"Medical Genetics Department Study Center of Congenital Malformations in Auvergne (Centre d'Etude des Malformations Cong\u00e9nitales en Auvergne)  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Uhrhammer","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Centre Jean Perri (Comprehensive Cancer Center)  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Francannet","sequence":"additional","affiliation":[{"name":"Medical Genetics Department Study Center of Congenital Malformations in Auvergne (Centre d'Etude des Malformations Cong\u00e9nitales en Auvergne)  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Arbre","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Centre Jean Perri (Comprehensive Cancer Center)  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Bidet","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Centre Jean Perri (Comprehensive Cancer Center)  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves\u2010Jean","family":"Bignon","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Centre Jean Perri (Comprehensive Cancer Center)  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1003-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9257-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5014"},{"key":"e_1_2_8_5_1","first-page":"73","article-title":"Chromosomal errors and reproductive failure","volume":"4","author":"Bernirschke K","year":"1974","journal-title":"Basic Life Sci"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120103"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Cytogenetics of pregnancy wastage","volume":"14","author":"Boue A","year":"1985","journal-title":"Adv Hum Genet"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1980.tb00955.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14713"},{"key":"e_1_2_8_11_1","unstructured":"INSEE \u2013 French National Institue for Statistics and Economic Studies.2010.https:\/\/www.insee.fr\/fr\/statistiques\/1291295. 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