{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:40:57Z","timestamp":1780598457729,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We determine the prevalence and trends of open neural tube defects (ONTDs) during 1991 to 2019 at the \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara (Mexico). Also, details of potential risks were obtained in 662 newborns, including those 143 patients with anencephaly and open spina bifida (OSB) classified as isolated (cases) and 519 controls. Data were analyzed using multivariable logistic regression. Among 267\u2009201 live births during the study period, 336 were born with ONTDs, yielding an overall prevalence of 12.6 per 10\u2009000. After folic acid (FA)\u2010related programs began in Mexico (2003\u20102019), only OSB showed a decline of 20.6%. For anencephaly, associated risks included relatives with neural tube defects (NTDs) (adjusted odds ratio [aOR]: 67.9, 95% confidence interval [95% CI]: 11.3\u2010409.8), pre\u2010pregnancy body mass index (BMI) \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> (aOR: 2.6, 95% CI: 1.1\u20106.0), insufficient gestational weight gain (aOR: 3.0, 95% CI: 1.3\u20107.1), parity \u22654 (aOR: 3.2, 95% CI: 1.3\u20107.7), and exposure to analgesic\/antipyretic drugs (aOR: 9.0; 95% CI: 2.5\u201033.0). For OSB, associated risks included consanguinity (aOR: 14.0, 95% CI: 3.5\u201055.9), relatives with NTDs (aOR: 22.4, 95% CI: 4.5\u2010112.9), BMI \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> (aOR: 2.5, 95% CI: 1.6\u20104.2), insufficient gestational weight gain (aOR: 1.9, 95% CI: 1.1\u20103.1), and exposures to hyperthermia (aOR: 2.3, 95% CI: 1.2\u20104.3), common cold (aOR: 6.8, 95% CI: 3.6\u201012.7), and analgesic\/antipyretic drugs (aOR: 3.6, 95% CI: 1.3\u201010.0). Our high rate probably results from exposures to preventable risks, most related to FA, indicating a need for strengthening existing FA\u2010related programs in Mexico.<\/jats:p>","DOI":"10.1111\/cga.12399","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T03:57:42Z","timestamp":1603943862000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara (Jalisco, Mexico)"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4626-148X","authenticated-orcid":false,"given":"Jorge Rom\u00e1n","family":"Corona\u2010Rivera","sequence":"first","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Mexico"},{"name":"\u201cDr. Enrique Corona\u2010Rivera\u201d Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center University of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Olvera\u2010Molina","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Jes\u00fas","family":"P\u00e9rez\u2010Molina","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. 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Menchaca\u201d Civil Hospital of Guadalajara  Guadalajara Mexico"},{"name":"\u201cDr. Enrique Corona\u2010Rivera\u201d Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center University of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Corona\u2010Rivera","sequence":"additional","affiliation":[{"name":"Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division \u201cDr. Juan I. 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