{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:38Z","timestamp":1747183898811,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["Grant Number 23112006"],"award-info":[{"award-number":["Grant Number 23112006"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interkinetic nuclear migration (INM) is an apicobasal (AB) polarity\u2010based regulatory mechanism of proliferation\/differentiation in epithelial stem\/progenitor cells. We previously documented INM in the endoderm\u2010derived tracheal\/esophageal epithelia at embryonic day (E) 11.5 and suggested that INM is involved in the development of both organs. We here investigated interorgan (trachea vs esophagus) and intraorgan regional (ventral vs dorsal) differences in the INM mode in the tracheal and esophageal epithelia of the mouse embryo. We also analyzed convergent extension (CE) and planar cell movement (PCM) in the epithelia based on cell distribution. The pregnant C57BL\/6J mice were intraperitoneally injected with 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine at E11.5 and E12.5 and were sacrificed 1, 4, 6, 8, and 12\u2009hours later to obtain the embryos. The distribution of labeled cell nuclei along the AB axis was chronologically analyzed in the total, ventral, and dorsal sides of the epithelia. The percentage distribution of the nuclei population was represented by histogram and the chronological change was analyzed statistically using multidimensional scaling. The interorgan comparison of the INM mode during E11.5\u2010E12.0, but not E12.5\u2010E13.0, showed a significant difference. During E11.5\u2010E12.0 the trachea, but not the esophagus, showed a significant difference between ventral and dorsal sides. During E12.5\u2010E13.0 neither organ showed regional differences. CE appeared to occur in both organs during E11.5\u2010E12.0 while PCM was unclear in both organs. These findings suggest a difference between the trachea and esophagus, and a regional difference in the trachea, not in the esophagus, in the INM mode, which may be related with the later differential organogenesis\/histogenesis of these organs.<\/jats:p>","DOI":"10.1111\/cga.12405","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T09:38:36Z","timestamp":1606642716000},"page":"82-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global pattern of interkinetic nuclear migration in tracheoesophageal epithelia of the mouse embryo: Interorgan and intraorgan regional differences"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-5902","authenticated-orcid":false,"given":"Dereje","family":"Getachew","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-5785","authenticated-orcid":false,"given":"Akihiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Uchimura","sequence":"additional","affiliation":[{"name":"Department of Anatomy Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6573-9434","authenticated-orcid":false,"given":"Jun","family":"Udagawa","sequence":"additional","affiliation":[{"name":"Department of Anatomy Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanako","family":"Mita","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Faculty of 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