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Along with the yearly trends in the birth prevalence of orofacial clefts in that area for the past 37\u2009years, we discuss whether the artificial abortion rate of fetuses with orofacial clefts has increased through the improved performance of ultrasonic imaging equipment. We also compare the yearly trends in the birth prevalence of congenital anomalies, including orofacial clefts, in Japan with those in other countries or areas where artificial abortion due to birth defects is legally permitted, and discuss the impact of improved accuracy of ultrasound imaging on the rate of artificial termination of pregnancy. The fact that the birth prevalence of orofacial clefts has basically remained unchanged for more than 30\u2009years, even with recent more detailed prenatal diagnosis based on the improvement of ultrasonic diagnostic equipment, has allowed us tentatively to conclude that prenatal diagnosis is not currently threatening the right to life of the fetuses with orofacial clefts.<\/jats:p>","DOI":"10.1111\/cga.12444","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T05:37:11Z","timestamp":1631252231000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in the birth prevalence of orofacial clefts in Japan: Has the birth prevalence of orofacial clefts been affected by improved accuracy of prenatal diagnosis?"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-2284","authenticated-orcid":false,"given":"Nagato","family":"Natsume","sequence":"first","affiliation":[{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"},{"name":"Department of Health Science Faculty of Psychological and Physical Science, Aichi Gakuin University  Nisshin Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyuki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Cleft Lip and Palate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Gerodontology and Home Care Dentistry School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waka","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry, Aichi Gakuin University  Nagoya 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Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagana","family":"Natsume","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of Dentistry, Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Foetal mortality. 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