{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:40:05Z","timestamp":1777959605387,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0109483"],"award-info":[{"award-number":["JP20ek0109483"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated folic acid (FA) intake and disturbing factors in pregnant women who visited our center in 2017. Among 1531 pregnant women, 45.1% of women initiated FA supplementation before pregnancy. The risk of failure of supplementation was significantly lower among women of \u226535 (adjusted odds ratio [aOR] 0.43) and 30\u201334\u2009years of age (aOR: 0.59) in comparison to women of &lt;30\u2009years of age, and among those conceived with timing\/artificial insemination of husband (aOR 0.47) and in vitro fertilization\/intracytoplasmic sperm injection (aOR 0.32) in comparison to those conceived naturally. The risk among those with 1 (aOR 1.44) or \u22652 previous deliveries (aOR 2.75) was significantly higher in comparison to nulliparous women. Young, multiparous women, and those with natural conception should be targeted to promote preconceptional FA intake.<\/jats:p>","DOI":"10.1111\/cga.12449","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T03:45:00Z","timestamp":1636429500000},"page":"42-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Periconceptional folic acid intake and disturbing factors: A single\u2010center study in Japan"],"prefix":"10.1111","volume":"62","author":[{"given":"Shunsuke","family":"Kamura","sequence":"first","affiliation":[{"name":"Center for Maternal\u2010Fetal Neonatal and Reproductive Medicine, National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Kyushu University School of Medicine  Fukuoka 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