{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:46Z","timestamp":1787014006788,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the safety of triptan use during pregnancy in a Japanese population, we descriptively analyzed the data on pregnancy and fetal outcomes from 128 pregnant women using triptans for migraine treatment at two Japanese facilities that provided counseling on drug exposure in pregnancy between 2001 and 2017. The risks of miscarriage, low birth weight, and preterm birth were similar to those reported in the demographic statistics in Japan. The incidence proportion of malformation was also within the baseline risk range. Accumulated data suggest that exposure to triptans during pregnancy does not clearly increase the risk of negative pregnancy and fetal outcomes. This finding can help reduce anxiety in pregnant women with migraines who are taking triptans.<\/jats:p>","DOI":"10.1111\/cga.12456","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T21:14:55Z","timestamp":1641244495000},"page":"78-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of triptan use during pregnancy in Japan: A case series"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-8062","authenticated-orcid":false,"given":"Yuko","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Medical Ethics and Medical Genetics Kyoto University School of Public Health  Kyoto Japan"},{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-7873","authenticated-orcid":false,"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and Medical Genetics Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikako","family":"Goto","sequence":"additional","affiliation":[{"name":"National Center for Child Health and Development The Japan Drug Information Institute in Pregnancy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and Medical Genetics Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-1354","authenticated-orcid":false,"given":"Takahito","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and Medical Genetics Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Ikeda\u2010Sakai","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Health Informatics, Graduate School of Medicine and School of Public Health Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Health Informatics, Graduate School of Medicine and School of Public Health Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Health Informatics, Graduate School of Medicine and School of Public Health Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Murashima","sequence":"additional","affiliation":[{"name":"National Center for Child Health and Development The Japan Drug Information Institute in Pregnancy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and Medical Genetics Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15440-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0993-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1062-4"},{"key":"e_1_2_7_5_1","unstructured":"The Chronic Headache Clinical Practice Guideline Development CommitteeClinical Practice Guideline for Chronic Headache 2013. Igakushoin; 2013 (in Japanese).https:\/\/www.jhsnet.net\/guideline_GL2013.html. Accessed November 27 2021."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.6.754"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12500"},{"key":"e_1_2_7_8_1","unstructured":"EUROCAT Guide 1.4: Instruction for the registration of congenital anomalies. EUROCAT Central Registry University of Ulster; 2013.https:\/\/eu\u2010rd\u2010platform.jrc.ec.europa.eu\/sites\/default\/files\/JRC\u2010EUROCAT\u2010Full\u2010Guide\u20101.4\u2010version\u201015\u2010Nov\u20102019.pdf. Accessed November 27 2021."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l869"},{"key":"e_1_2_7_10_1","unstructured":"Ministry of Health Labour and Welfare. Vital statistics.https:\/\/www.mhlw.go.jp\/toukei\/list\/81-1.html"},{"key":"e_1_2_7_11_1","first-page":"279","article-title":"Medications in pregnancy and lactation: assessment of risks to fetus and infants","volume":"18","author":"Hayashi M","year":"2011","journal-title":"Organ Biol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14709"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00480.x"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cga.12456","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:37:14Z","timestamp":1693111034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,13]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/cga.12456"],"URL":"https:\/\/doi.org\/10.1111\/cga.12456","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,13]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}