{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:06:42Z","timestamp":1793084802634,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prior studies have explored the links between congenital anomalies and assisted reproduction techniques, among other factors. However, it remains unclear whether a particular technique harbors an inherent risk of major congenital anomalies, either cumulatively or in an organ\u2010specific manner. A meta\u2010analysis was conducted using relevant studies from inception to February 2023 using six databases and two appropriate registers. Sources of heterogeneity were explored using sub\u2010group analysis, using study weight, risk of bias and geographical location of original studies. Neonates conceived through assisted reproduction appear to have a higher risk of major congenital anomalies compared to naturally conceived neonates, OR 0.67 [95% CI 0.59, 0.76], I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200997%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001, with neonates conceived through intracytoplasmic sperm injection (ICSI) at a 9% higher chance of being affected in comparison to neonates conceived through in vitro fertilization (IVF). The increase in cardiac, gastrointestinal (GI), and neurological congenital anomalies appears to be independent of the assisted reproduction technique, while urogenital and musculoskeletal (MSK) anomalies were found to be increased in ICSI compared with IVF, OR 0.83 [95% CI 0.69, 0.98];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03, I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%, and OR 0.65 [95% CI 0.49, 0.85];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002, I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200980%, respectively. Neonates conceived using assisted reproduction techniques appear to be at higher risk of major congenital anomalies, with a higher risk attributable to conception using ICSI. The increase in cardiac, neurological, and GI congenital anomalies does not appear to be technique\u2010specific, while the opposite held true for urogenital and MSK anomalies.\n                  <\/jats:p>","DOI":"10.1111\/cga.12561","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T04:14:40Z","timestamp":1712290480000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assisted reproduction and congenital malformations: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-8270","authenticated-orcid":false,"given":"Meenakshi","family":"Veeramani","sequence":"first","affiliation":[{"name":"School of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerujah","family":"Balachandren","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Medicine St Georges University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Brighton and Sussex Medical School  East Sussex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio F.","family":"Corno","sequence":"additional","affiliation":[{"name":"School of Engineering University of Leicester  Leicester UK"},{"name":"Faculty of Science and Engineering Manchester Metropolitan University  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Mavrelos","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4470-5267","authenticated-orcid":false,"given":"Stavroula L.","family":"Kastora","sequence":"additional","affiliation":[{"name":"EGA Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"World Health Organization Factsheets Congenital disorders [Internet]","author":"World Health Organization","year":"2023"},{"key":"e_1_2_11_3_1","volume-title":"NHS Digital NCARDRS Congenital Anomaly Official Statistics Report 2020 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