{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:44:32Z","timestamp":1793814272871,"version":"4.6.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K08500"],"award-info":[{"award-number":["17K08500"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07855"],"award-info":[{"award-number":["22K07855"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During pregnancy, the maternal environment is critical for normal ontogeny and central nervous system development. Occasionally, prenatal exposure to environmental factors affects tissue architecture and functional development of the brain, which causes developmental disorders, including disorders of the autism spectrum. One of these environmental factors is the exposure to infectious diseases during pregnancy. In this study, we generated mice with infectious disease\u2010induced inflammation by prenatal exposure to 200\u2009\u03bcg\/kg polyinosinic\u2013polycytidylic acid sodium salt [Poly(I:C)] at embryonic day 12.5 and analyzed their phenotypes on 30\u2010weeks\u2010old. We attempted to detect abnormalities in spontaneous activity and social interaction, which may be indicators of developmental disorder\u2010like behavioral abnormalities, in free\u2010ranging behaviors in multiple rearing environments using multiple animal positioning systems and UMATracker in mice with fetal inflammation. Increased spontaneous activity and abnormal social interactions were observed in mice in the Poly(I:C)\u2010treated group compared with those in the control group. Prenatal exposure to Poly(I:C) increased motor activity and decreased social interaction, and social behavior in prenatally treated mice in a multiple\u2010individual rearing environment. Poly(I:C) exposure during the fetal period resulted in developmental disorder\u2010like behavioral abnormalities, such as increased activity and abnormal social interactions, even after maturation in a multiple\u2010individual rearing environment. This experimental method may provide a new way to analyze the behavior of mouse models of developmental disorders in a multiple\u2010individual rearing environment, in which free\u2010ranging behavior is possible.<\/jats:p>","DOI":"10.1111\/cga.12563","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T02:45:04Z","timestamp":1711939504000},"page":"125-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection of abnormal behaviors in prenatal Poly(I:C) exposed mice in a group\u2010rearing environment"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3980-5976","authenticated-orcid":false,"given":"Munekazu","family":"Komada","sequence":"first","affiliation":[{"name":"Mammalian Embryology Laboratory, Department of Life Science, Faculty of Science and Engineering Kindai University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Kiriyama","sequence":"additional","affiliation":[{"name":"Mammalian Embryology Laboratory, Department of Life Science, Faculty of Science and Engineering Kindai University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Mammalian Embryology Laboratory, Department of Life Science, Faculty of Science and Engineering Kindai University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Harada","sequence":"additional","affiliation":[{"name":"Computational Life Science Laboratory, Department of Energy and Materials, Faculty of Science and Engineering Kindai University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Kawashita","sequence":"additional","affiliation":[{"name":"Computational Life Science Laboratory, Department of Energy and Materials, Faculty of Science and Engineering Kindai University  Osaka 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Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T02:30:27Z","timestamp":1714962627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,31]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/cga.12563"],"URL":"https:\/\/doi.org\/10.1111\/cga.12563","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,31]]},"assertion":[{"value":"2023-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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