{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:02:09Z","timestamp":1789387329451,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to establish a specific and definite connection between non\u2010syndromic orofacial cleft patients and associated congenital heart disease (CHD). Following PRISMA guidelines, selective databases were searched for data collection. Studies showing a definite association of CHD with orofacial cleft were included, and studies non\u2010specific of the association of orofacial cleft with CHD were excluded. Data extraction criteria were study design, frequency of CHD in overall non\u2010syndromic orofacial cleft and in specific cleft type, and most prevalent congenital cardiac anomaly. DerSimonian Laird random effects model was used to estimate the pooled proportion of CHD, along with corresponding 95% confidence intervals (CIs) for each measure. Publication bias was assessed using Fail\u2010Safe N analysis and the Rosenthel approach. Of a total of 182 articles searched, only 30 studies were assessed. The overall pooled estimate of the proportion of CHD in total cleft lips\/palates was 16% (95% CI: 13\u201319). The odds of developing CHD in cleft palates was 4.08 times more as compared to cleft lips with 95% CIs of 3.86\u20134.33, and 1.65 more as compared to cleft lips and palates both with 95% CI of 1.52\u20131.68. We affirm the upsurging prevalence of CHD in non\u2010syndromic cleft children and vehemently propose that it is of utmost importance to inculcate it in practice and policy\u2010making to screen all non\u2010syndromic orofacial cleft children for congenital cardiac anomaly. This study was registered on PROSPERO (ID no. CRD42023391597) on February 24, 2023.<\/jats:p>","DOI":"10.1111\/cga.12567","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:04:53Z","timestamp":1711458293000},"page":"143-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Congenital cardiac anomalies in non\u2010syndromic cleft lip and cleft palate patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"given":"Bindey","family":"Kumar","sequence":"first","affiliation":[{"name":"Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-5867","authenticated-orcid":false,"given":"Priyankar","family":"Singh","sequence":"additional","affiliation":[{"name":"Unit of Cranio\u2010Maxillo\u2010Facial Surgery Post Graduate Institute of Dental Education &amp; Research, Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Community and Family Medicine All India Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulika","family":"Singh","sequence":"additional","affiliation":[{"name":"Community and Family Medicine Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimmi","family":"Singh","sequence":"additional","affiliation":[{"name":"Oral Medicine and Radiology Post Graduate Institute of Dental Education &amp; Research, Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kriti","sequence":"additional","affiliation":[{"name":"Prosthodontist and Anaplastologist Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Singh","sequence":"additional","affiliation":[{"name":"Periodontology Post Graduate Institute of Dental Education &amp; Research, Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"General Medicine, Unit of Emergency Medicine Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Mishra","sequence":"additional","affiliation":[{"name":"Conservative and Endodontics Post Graduate Institute of Dental Education &amp; Research, Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbind Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Post Graduate Institute of Dental Education &amp; Research, Indira Gandhi Institute of Medical Sciences Patna Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4802808"},{"key":"e_1_2_9_3_1","first-page":"622","article-title":"Congenital oral clefts and dermatoglyphics","volume":"20","author":"Balgir RS","year":"1984","journal-title":"Isr J Med Sci"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31447"},{"key":"e_1_2_9_6_1","volume-title":"Global Registry and Database on Craniofacial Anomalies: Report of a WHO Registry Meeting on Craniofacial Anomalies","author":"Mossey P","year":"2003"},{"key":"e_1_2_9_7_1","article-title":"Elevated infant mortality rate among Dutch oral cleft cases: a retrospective analysis from 1997 to 2011","volume":"1","author":"Nunen DP","year":"2014","journal-title":"Front Surg"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01577.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001069"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"key":"e_1_2_9_11_1","unstructured":"The jamovi Project.jamovi. 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