{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:22:34Z","timestamp":1785370954638,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polydactyly is typically observed as isolated and sporadic occurrences, although familial cases do exist, albeit with lower frequency, manifesting in various inheritance patterns. In around 30% of polydactyly cases, there exists a familial history, suggesting the probable involvement of a single gene. Given its potential for hereditary transmission, thorough investigation of the patients' parents, first\u2010degree relatives, grandparents, and even great\u2010grandparents for similar disorders becomes imperative. In our clinic, we conducted an analysis focusing on patients presenting with foot polydactyly, along with occurrences of polydactyly among their first\u2010 and second\u2010degree relatives spanning two to three generations of family history. The study encompassed three patients and their respective families, including a pair of siblings. We speculate that the inheritance type in our cases was autosomal dominant. Among our patients, one presented with central polydactyly, while the remaining patients and all familial cases displayed postaxial polydactyly. In terms of morphologic classification, one patient had a Y\u2010shaped metatarsal, another had a T\u2010shaped metatarsal, and the third patient exhibited a duplicated ray\u2010shaped anomaly. In our review of the literature, we haven't come across a case spanning three generations like the ones we encountered. Additionally, the presence of a transverse accessory extensor tendon between both extensor tendons in cases with T\u2010 and Y\u2010shaped metatarsals intrigued us from an anatomical perspective. Our goal is to present these rare cases of congenital familial polydactyly spanning three generations, highlighting the anatomical variations observed and aiming to contribute to the existing body of literature on the subject.<\/jats:p>","DOI":"10.1111\/cga.12578","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T09:13:32Z","timestamp":1720257212000},"page":"228-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Congenital three generation wide familial non\u2010syndromic polydactyly"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-5538","authenticated-orcid":false,"given":"\u00d6zg\u00fcr","family":"Agdo\u011fan","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive and Aesthetic Surgery Tekirda\u011f Nam\u0131k Kemal University Faculty of Medicine  Tekirda\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkJPlastSurg.2016.1945"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12276"},{"key":"e_1_2_9_4_1","unstructured":"G\u00fcn\u0130 M\u00fcngenE BabacanA MuhcuM Kurdo\u011fluM AtayV.El ve Aya\u011f\u0131n Polidaktilisi: \u00dc\u00e7 Olgunun Sunumu ve Polidaktili Olgular\u0131nda G\u00fcncel Prenatal ve Postnatal Uygulamalar\u0131n G\u00f6zden Ge\u00e7irilmesi. Zeynep kamil t\u0131p b\u00fclteni cilt: 40 y\u0131l: 2009 say\u0131:3."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2015.08.015"},{"key":"e_1_2_9_6_1","unstructured":"\u0130rgitK Ta\u015fba\u015fBA Ay\u015e.Do\u011fumsal Ayak Parmak Bozukluklar\u0131. T\u00fcrk Ortopedi ve Travmatoloji Birli\u011fi Derne\u011fi Dergisi 2009 Cilt: 8 Say\u0131: 3\u20134."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199205000-00014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2008.12.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2000.6457"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-014-9201-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.03.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2005.07.021"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2013.12.023"},{"issue":"4","key":"e_1_2_9_14_1","first-page":"401","article-title":"Sporadic familial polydactyly","volume":"14","author":"Karaaslan O","year":"2003","journal-title":"Genet Couns"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12163"},{"key":"e_1_2_9_16_1","first-page":"396","volume-title":"Pediatric Orthopedics in Practice","author":"Heft F","year":"2007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2009.01.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2009.02.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2001.9419"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10774"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22609"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912818107"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.018945"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2007.00943.x"},{"key":"e_1_2_9_25_1","first-page":"376","article-title":"Polydactyly of the foot literature review and case presentations","volume":"68","author":"Galois L","year":"2002","journal-title":"Acta Orthop Belg"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"205","article-title":"A new surgical technique for an unusual case of fibular (postaxial) polydactyly","volume":"23","author":"K\u00fc\u00e7\u00fckdurmaz F","year":"2016","journal-title":"Van T\u0131p Derg"},{"key":"e_1_2_9_27_1","first-page":"356","article-title":"Classification of postaxial polydactyly of the foot","volume":"27","author":"HoSeong LS","year":"2006","journal-title":"FAI"},{"issue":"4","key":"e_1_2_9_28_1","first-page":"405","article-title":"Polydactyly a genetic study in South America","volume":"25","author":"Castilla E","year":"1973","journal-title":"Am J Hum Genet"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPB.0b013e32832d8487"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.21102"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T04:50:39Z","timestamp":1736398239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/cga.12578"],"URL":"https:\/\/doi.org\/10.1111\/cga.12578","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,6]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}