{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:47Z","timestamp":1787014007189,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This systematic review and meta\u2010analysis evaluated the safety of montelukast in treating asthma during pregnancy, focusing on maternal and fetal outcomes such as congenital anomalies (CA), preterm delivery, low birthweight, spontaneous abortion, gestational diabetes mellitus, and preeclampsia. A comprehensive literature search was conducted in Google Scholar, PubMed, and the Cochrane Library databases from inception until April 30, 2024. The eligible studies assessed the safety of montelukast for asthma treatment during pregnancy. The review suggests that montelukast use during pregnancy may not significantly increase the risk of major CA. The pooled results yielded risk ratio (RR) for CA was 1.13 [95% CI (0.74, 1.73),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.56,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%]. Montelukast may be associated with preterm delivery and a low birthweight odds ratio (OR) of 1.82 [95% CI (1.35, 2.45),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%]. No significant risks were found concerning neurodevelopmental outcomes. The associations with spontaneous abortion were inconclusive [OR\u2009=\u20091.03, 95% CI (0.72, 1.5),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.86,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200973%], highlighting the need for further research. This comprehensive review underscores the importance of further investigating the safety profile of montelukast during pregnancy. While the overall findings indicate a relatively favorable safety profile, especially regarding major CA, careful consideration is needed for the potential risks of preterm delivery and low birthweight.\n                  <\/jats:p>","DOI":"10.1111\/cga.12581","type":"journal-article","created":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T23:39:55Z","timestamp":1723419595000},"page":"220-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Montelukast use in pregnancy: A systematic review and meta\u2010analysis of maternal and fetal outcomes in asthma treatment"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-9852","authenticated-orcid":false,"given":"Areeba","family":"Fareed","sequence":"first","affiliation":[{"name":"Karachi Medical and Dental College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5939-7486","authenticated-orcid":false,"given":"Dima","family":"Siblini","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-700X","authenticated-orcid":false,"given":"Rayyan","family":"Vaid","sequence":"additional","affiliation":[{"name":"Karachi Medical and Dental College  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Farhat","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Rida","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4837-8114","authenticated-orcid":false,"given":"Abdulrahmon","family":"Moradeyo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Ladoke Akintola University of Technology  Ogbomosho Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ahsan","family":"Khan","sequence":"additional","affiliation":[{"name":"National Institute of Liver and Gastrointestinal Diseases Dow University Hospital, Ojha Campus  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000538"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.08.029"},{"key":"e_1_2_8_4_1","unstructured":"Global Initiative for Asthma.2022 GINA main report \u2013 Global Initiative for Asthma \u2013 GINA.2022. Accessed July 19 2024.https:\/\/ginasthma.org\/gina-reports\/"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2012.120008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9046842"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2009119"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.4.1660"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2022.06.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2023.44.220077"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143580"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1207533"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010010\u20109491\u2010z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1934"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12471"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23621"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0713-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.618"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-018-0046-5"},{"key":"e_1_2_8_21_1","unstructured":"Merck Pregnancy Registry Program.Seventh annual report on exposure during pregnancy from the Merck Pregnancy Registry for SINGULAIR (montelukast sodium). North Wales (PA): 2005. 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