{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:18:37Z","timestamp":1778181517011,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this study was to conduct qualitative research by clarifying the thoughts of pregnant women undergoing non\u2010invasive prenatal testing (NIPT) in Japan, to collect evidence to provide information and psychosocial support in genetic counseling (GC). We attempted to conduct qualitative research to provide support for GC and the society in relation to children with special needs, by clarifying the thoughts of pregnant women undergoing NIPT. Between January 2016 and December 2017, we administered an open\u2010ended questionnaire to pregnant Japanese women undergoing NIPT to clarify their ethical views in relation to children with special needs. The target population included 754 pregnant women who described their feelings and thoughts about undergoing NIPT and about children with special needs. Pregnant women undergoing NIPT have a variety of various mixed feelings and concerns. We classified the feelings and thoughts of pregnant women who underwent NIPT into the following four primary categories (multiple classifications): (1) perception about people with special needs (18.0%); (2) relation between NIPT and life selection (22.3%); (3) attitudes towards undergoing NIPT (47.5%); and (4) negative feelings and thoughts about raising children with special needs (48.1%). Most pregnant women undergoing NIPT expressed negative feelings and raising children with special needs. These feelings and thoughts may be one of the reasons why pregnant women undergo NIPT. In GC, it is important to also provide wide information on the social support and the current situation in the actual life of children with special needs.<\/jats:p>","DOI":"10.1111\/cga.12586","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T21:09:29Z","timestamp":1732568969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feelings and thoughts about life selection in pregnant women undergoing non\u2010invasive prenatal testing in Japan"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5278-7074","authenticated-orcid":false,"given":"Eri","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Clinical and Molecular Genetics Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-1289","authenticated-orcid":false,"given":"Nobuhiro","family":"Suzumori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Clinical and Molecular Genetics Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Clinical Genetics Iwate Medical University School of Medicine  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Clinical and Molecular Genetics Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Komata","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Osaka Women's and Children's Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Sugiura\u2010Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Clinical and Molecular Genetics Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"296","article-title":"DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as down syndrome: an international collaborative study","volume":"14","author":"Palomaki GE","year":"2012","journal-title":"Genetics"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S67124"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13841"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4637"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4539"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13373"},{"key":"e_1_2_10_8_1","first-page":"2110","article-title":"The Japan Society of Obstetrics and Gynecology 2011 Report of the ethics committee and registration and investigation subcommittee of the Japan Society of Obstetrics and Gynecology","volume":"64","author":"Japan Society of Obstetrics and Gynecology","year":"2012","journal-title":"Acta Obstet Gynaecol Japan"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090314-050000"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-018-0267-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.257"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702006074"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2012.745490"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4427"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3886"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353523"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2816"},{"key":"e_1_2_10_18_1","first-page":"8","article-title":"Decision\u2010making factors in prenatal testing: a systematic review","volume":"13","author":"Di Mattei V","year":"2021","journal-title":"Health Psychol Open"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.16052"},{"key":"e_1_2_10_20_1","unstructured":"Cabinet Office Government.Report on the 2023 Opinion poll on people with disabilities. [PDF file]. Retrieved 05\/07\/02023 fromhttps:\/\/survey.gov-online.go.jp\/r04\/r04-shougai\/gairyaku.pdf"},{"key":"e_1_2_10_21_1","unstructured":"Cabinet Office Government.Report on the 2006 International comparative study on the promotion of social participation of the people with disabilities [Internet]. Retrieved 05\/07\/02023 fromhttps:\/\/www8.cao.go.jp\/shougai\/suishin\/tyosa\/hikaku\/gaiyou.html"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35990"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074840720975167"},{"key":"e_1_2_10_24_1","unstructured":"Steering Committee for Prenatal Testing and Certification System.[Internet] Retrieved 05\/07\/2023. fromhttps:\/\/www.jams-prenatal.jp\/"},{"key":"e_1_2_10_25_1","unstructured":"Informational Website on Pregnancy Testing.[Internet] Retrieved 03\/07\/2024 from.https:\/\/prenatal.cfa.go.jp\/"},{"key":"e_1_2_10_26_1","unstructured":"Cabinet Office.Government Report on the 2020 International attitude survey on society with declining birth rate. [PDF file] Retrieved 05\/07\/02023 from.https:\/\/warp.da.ndl.go.jp\/info:ndljp\/pid\/13024511\/www8.cao.go.jp\/shoushi\/shoushika\/research\/r02\/kokusai\/pdf\/zentai\/s3_1.pdf"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1494"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cga.12586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:16:26Z","timestamp":1766481386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cga.12586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/cga.12586"],"URL":"https:\/\/doi.org\/10.1111\/cga.12586","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"2024-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12586"}}